E-cadherin, β-catenin, Cyclin D1在胃腺癌中的表达及临床意义
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王 渝, 柯昌庶, 赵 秋, 马松林, 龚 勇, 杨 芳
胃癌;免疫组织化学;E-cadherin;b-catenin;CyclinD1王渝,柯昌庶,赵秋,马松林,龚勇,杨芳.E-cadherin,b-catenin,CyclinD1在胃腺癌中的表达及临床意义. 世界华人消化杂志2007;15(4)403-407,E-cadherin,β-ca
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王渝, 赵秋, 马松林, 龚勇, 杨芳, 华中科技大学同济医学院附属同济医院消化内科 湖北省武汉市 430030
柯昌庶, 华中科技大学同济医学院附属同济医院病理科 湖北省武汉市 430030
通讯作者: 赵秋, 430030, 湖北省武汉市汉口解放大道1095号, 华中科技大学同济医学院附属同济医院消化内科.
tongji461@sina.com
电话: 027-83663611
收稿日期: 2006-10-26 接受日期: 2006-11-03
Expression of E-cadherin, β-catenin and Cyclin D1 in gastric adenocarcinoma and their clinical significances
Yu Wang, Chang-Shu Ke, Qiu Zhao, Song-Lin Ma, Yong Gong, Fang Yang
Yu Wang, Qiu Zhao, Song-Lin Ma, Yong Gong, Fang Yang,Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan 430030, Hubei Province, China
Chang-Shu Ke,Department of Pathology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to:Qiu Zhao, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. tongji461@sina.com
Received:2006-10-26 Accepted:2006-11-03
AbstractAIM: To investigate the expression of E-cadherin, b-catenin and Cyclin D1 and their relationships and clinical pathological features in gastric adenocarcinoma.
METHODS: Immunohistochemical SP method was used to determine the expression of E-cadherin, b-catenin and Cyclin D1 protein in 73 cases of gastric adenocarcinoma tissues and 18 cases of normal gastric mucosal tissues.
RESULTS: Positive staining for E-cadherin and b-catenin was observed on the cellular membrane of epithelial cells in normal gastric mucosal tissues. The aberrant expression of E-cadherin andb-catenin were observed in the cytoplasm and/or cellular nucleus of gastric cancer cells. The aberrant expression rates of E-cadherin and b-catenin were 63.01% (46/73) and 56.16% (41/73) in gastric adenocarcinoma, respectively, which were associated with the differentiation degree, TNM stages, depth of infiltration and lymph node metastasis, but not with the gender, age and tumor size ......
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