埃索美拉唑对胃黏膜的保护作用及其机制
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乐桥良, 张志坚, 林克荣
埃索美拉唑;胃黏膜损伤;细胞保护;一氧化氮乐桥良,张志坚,林克荣.埃索美拉唑对胃黏膜的保护作用及其机制. 世界华人消化杂志2007;15(4)390-393,乐桥良,张志坚,林克荣,通讯作者:,电话:,收稿日期:,接受日期:,Effecto
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乐桥良, 张志坚, 林克荣, 中国人民解放军南京军区福州总医院消化科 福建省福州市 350025
通讯作者: 乐桥良, 350025, 福建省福州市西二环北路156号, 中国人民解放军 南京军区福州总医院消化科.
leqliang@sohu.com
电话: 0591-87893856
收稿日期: 2006-12-21 接受日期: 2006-12-27
Effect of esomeprazole on gastric mucosal lesion and its mechanism in rats
Qiao-Liang Le, Zhi-Jian Zhang, Ke-Rong Lin
Qiao-Liang Le, Zhi-Jian Zhang, Ke-Rong Lin,Department of Gastroenterology, Fuzhou General Hospital of Chinese PLA Nanjing Military Command, Fuzhou 350025, Fujian Province, China
Correspondence to:Qiao-Liang Le, Department of Gastroenterology, Fuzhou General Hospital of Chinese PLA Nanjing Military Command, 156 Xi’erhuan North Road, Fuzhou 350025, Fujian Province, China. leqliang@sohu.com
Received:2006-12-21 Accepted:2006-12-27
AbstractAIM: To observe the protective effect of esome-prazole on gastric mucosa and its mechanism.
METHODS: Before the model of gastric mucosal lesion was made by pure alcohol, esomeprazole (20 mg/kg) was intragastrically administered while Nw-nitro-L-arginine methyl ester (L-NAME, 4 mg/kg) and L-arginine (250 mg/kg) were intravenously injected into the rats. Gastric mucosal blood flow (GMBF) was measured with laser Doppler flowmetry (LDF), while gastric mucosal and serum NO-2/NO-3 levels were examined by cadmium granulation reduction and colorimetric method. The changes of ulcer index and the severity of tissue necrosis and neutrophil infiltration were also observed.
RESULTS: The ulcer index was significantly lower in the rats with esomeprazole pretreatment than that in the model rats (5.6 ± 2.2 vs 25.3 ± 2.4, P < 0.01), and the degree of tissue necrosis and neutrophil infiltration were also much milder (P < 0.01). Prior administration of L-NAME obviously inhibited the protective effect of esomeprazole was on gastric mucosa, but the inhibition was alleviated by L-arginine ......
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