IL-1β致乙酸性胃溃疡复发大鼠的比较蛋白质组学分析
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申定珠, 李家邦, 叶 川, 凌江红, 马国添, 叶仁群, 黄国栋, 蒋荣鑫
比较蛋白质组学;胃溃疡复发;二维凝胶电泳;质谱;免疫组化申定珠,李家邦,叶川,凌江红,马国添,叶仁群,黄国栋,蒋荣鑫.IL-1b致乙酸性胃溃疡复发大鼠的比较蛋白质组学分析. 世界华人消化杂志2007;15(4)332-339,申定珠
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申定珠, 李家邦, 凌江红, 叶仁群, 黄国栋, 蒋荣鑫,中南大学湘雅医院中西医结合研究所 湖南省长沙市 410008
叶川,中南大学湘雅医院骨科 湖南省长沙市 410008
马国添,中南大学湘雅医院心内科 湖南省长沙市 410008
申定珠,中南大学湘雅医院中西医结合研究所2004级在读博士研究生, 主治医师, 主要从事内科消化系统疾病的中西医结合临床与实验研究.湖南省自然科学基金资助项目, No. 04JJ3099
通讯作者:蒋荣鑫, 410008, 湖南省长沙市湘雅路87号, 中南大学湘雅医院中西医结合研究所. shensan13@163.com
电话:0731-4327031
收稿日期:2006-10-31 接受日期:2006-12-01
Comparative proteomics analysis on acetic acid-induced gastric ulcer recurrence caused by interleukin-1β
Ding-Zhu Shen, Jia-Bang Li, Chuan Ye, Jiang-Hong Ling, Guo-Tian Ma, Ren-Qun Ye, Guo-Dong Huang, Rong-Xin Jiang
Ding-Zhu Shen, Jia-Bang Li, Jiang-Hong Ling, Ren-Qun Ye, Guo-Dong Huang, Rong-Xin Jiang, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Chuan Ye, Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Guo-Tian Ma, Department of Cardiology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Supported by the Natural Science Foundation of Hunan Province, No. 04JJ3099
Correspondence to: Dr. Rong-Xin Jiang, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha 410008, Hunan Province, China. shensan13@163.com
Received: 2006-10-31 Accepted: 2006-12-01
AbstractAIM:To screen the proteins related to gastric ulcer recurrence and find out the mechanism of gastric ulcer recurrence through proteomic tools.
METHODS: Acetic acid was used to prepare the model of gastric ulcer, whose occurrence was induced by interleukin-1b (IL-1b). Two-dimensional gel electrophoresis (2-DE) was performed to separate the total proteins of ulcerative tissues and normal tissues ......
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