p-STAT3与E-cadherin在胰腺癌中的表达及其临床意义
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黄 陈, 裘正军, 胡宏惠, 江 弢, 朱 麟, 张 放, 黄克俭, 曹 俊
胰腺癌;信号传导与转录激活因子3;E-钙黏附素;侵袭;转移黄陈,裘正军,胡宏惠,江弢,朱麟,张放,黄克俭,曹俊.p-STAT3与E-cadherin在胰腺癌中的表达及其临床意义. 世界华人消化杂志2007;15(4)381-386 p-STAT3和E-cad在胰腺组织中的表达
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黄陈, 裘正军, 胡宏惠, 江弢, 朱麟, 张放, 黄克俭, 曹俊, 上海交通大学附属第一人民医院普外科 上海市 200080
胡宏惠, 上海交通大学附属第一人民医院病理科 上海市 200080
通讯作者: 裘正军, 200080, 上海武进路85号, 上海交通大学附属第一人民医院普外科. qiuwryb@online.sh.cn
电话: 021-63240090-3091 传真: 021-63240825
收稿日期: 2006-11-14 接受日期: 2006-12-08
Expression of p-STAT3 and E-cadherin in pancreatic cancer and their clinical significances
Chen Huang, Zheng-Jun Qiu, Hong-Hui Hu, Tao Jiang, Lin Zhu, Fang Zhang, Ke-Jian Huang, Jun Cao
Chen Huang, Zheng-Jun Qiu, Tao Jiang, Lin Zhu, Fang Zhang, Ke-Jian Huang, Jun Cao, Department of General Surgery, the First People's Hospital of Shanghai Jiao Tong University, Shanghai 200080, China
Hong-Hui Hu, Department of Pathology, the First People's Hospital of Shanghai Jiao Tong University, Shanghai 200080, China
Correspondence to: Zheng-Jun Qiu, Department of General Surgery, the First People's Hospital of Shanghai Jiao Tong University, Shanghai 200080, China. qiuwryb@online.sh.cn
Received: 2006-11-14 Accepted: 2006-12-08
AbstractAIM: To investigate the expression of phospho-rylated signal transduction and activators of transcription-3 (p-STAT3) and E-cadherin as well as their correlations with the clinicopathological parameters in pancreatic cancer, and to reveal the role of STAT3 signal pathway in the invasion and metastasis of pancreatic cancer.
METHODS: Immunohistochemistry was used to detect the expression of p-STAT3 and E-cadherin in 34 cases of pancreatic cancer and 10 cases of normal pancreatic tissues. Cell invasion assay kit was used to examine the invasion ability of pancreatic cancer cells SW1990 and CaPan-2. Western blot and electrophoretic mobility shift assay (EMSA) were applied to detect the protein expression of p-STAT3 and STAT3 DNA-binding activity in SW1990 and CaPan-2 cells.
RESULTS: Immunohistochemistry revealed high expression of p-STAT3 (64 ......
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