急性冠状动脉综合征患者血清MCP-1的变化及临床意义 (pdf)

    【摘要】 目的 研究急性冠状动脉综合征(ACS)患者血清单核细胞趋化蛋白-1(MCP-1)的变化及临床意义。方法 选取ACS患者80例，其中急性心肌梗死(AMI)40例，不稳定型心绞痛(UAP)40例。ACS患者经治疗后，进行6个月随访。同时选取正常对照40例。采用酶联免疫吸附法测定上述病例和对照者血清中的MCP-1并进行统计学分析。结果 AMI组、UAP组MCP-1均显著高于对照组(P<0.05)，AMI组与UAP组组间MCP-1差异无显著性(P>0.05)；并在出院6个月后随访时，发现MCP-1较住院治疗前明显降低并且差异有显著性(P<0.05)， AMI组与UAP组组间患者血清MCP-1仍差异无显著性(P>0.05)。结论 血清中MCP-1随ACS病情变化而改变，可以作为诊断和预测ACS的指标，并可以反映病情的轻重及稳定情况，在临床上有较高的应用价值。

    【关键词】 急性冠状动脉综合征；单核细胞趋化蛋白-1；巨噬细胞

    Study on the changes and clinical significance of serum levels of MCP-1 in patients with acute coronary syndrome

    XU Chong-li,WANG Qi,ZHANG Ji-nan, et al.Cardiovascular Department of Jiangning Hospital, Nanjing 210000,China

    【Abstract】 Objective To study on the changes and clinical significance of serum levels of MCP-1, in patients with acute coronary syndrome.Methods The samples included 40 cases with acute myocardial infarction(AMI)and 40 patients with unstable angina pectons(UAP). All patients were followed-up for 6 months, meanwhile, in contrast, 40 normal people were selected to enter into the study. Serum levels of MCP-1 were measured by the way of ELISA.Results Serum levels of MCP-1 were significantly increased in the ACS group than those in the control group, and were significantly decreased afte 4 months treatment.Conclusion Serum levels of MCP-1 had been changed in the patients of ACS, may be used as the means of ACS diagnosis and a useful factor of reflecting the change of ACS. ......