大肠癌；P53；CerbB2；ras(调查研究)

P53,CerbB2,rasP21,nm23H1基因表达与大肠癌淋巴结转移的关系

http://www.100md.com 《河北医药》 2006年第12期

大肠癌；P53；CerbB2；ras,P21；nm23H1,,大肠癌；P53；CerbB2；ras,P21；nm23H1,1资料与方法,2结果,3讨论

     摘要】目的探讨大肠癌组织中癌基因和抑癌基因在大肠癌淋巴转移中的作用。方法利用免疫组化方法(SP法)检测大肠癌组织中癌基因和抑癌基因。结果 224例大肠癌患者中，淋巴结的转移率随分化程度降低而增高；随癌组织浸润深度增加，淋巴结的转移率明显提高；淋巴结转移的阳性率还随癌基因及其产物P53、CerbB2、rasP21的出现而增加，而随nm23H1的表达而降低。结论癌基因、抑癌基因的检测将有助于研究肿瘤淋巴转移的原因和机制，并对淋巴转移进行预测。

    【关键词】大肠癌；P53；CerbB2；ras P21；nm23H1

    P53,CerbB2,rasP21, nm23H1's expression and lymphatic metastasis in human colorectal carcinoma LV Bingrong,TAN Bibo, HAN Jie,et al.Department of Surgery, Hebei Provincial People' s Hospital, Shijiazhuang 050051

    【Abstract】 Objective To investigate the effect of P53, rasP21, nm23 H1 genes on lymphatic metasasis in human colorectal carcinoma.Methods The expression of P53, rasP21,CerbB2 and nm23 H1 in human colorectal carcinoma were studied immunohistochemically (SP). Results Of 224 cases of colorectal carcinoma the lymphatic metastasis were significantly higher in the primary colorectal carcinomas with tissue infiltration to subserosa (P<0.01).The lymphatic metastasis were significantly higher in P53,CerbB2,rasP21 positive expression (P<0.05) and negative expression of nm23H1 (P<0.05).Conclusion The expression of P53,CerbB2, rasP21 and nm23H1 were associated lymphatic metastasis in human colorectal carcinoma. These findings suggest a potential role of P53, C-erbB2, rasP21 and nm23H1 in lymphatic metastasis in human colorectal carcinoma angiogenesis. ......

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