胃黏膜不典型增生患者血浆同型半胱氨酸和血清叶酸水平的关系及叶酸补充的疗效 (pdf)

    【摘要】 目的 了解胃黏膜不典型增生患者血浆同型半胱氨酸(Hcy)与血清叶酸水平，并探讨其关系。方法 研究包括29例胃黏膜不典型增生患者和25名健康正常人，血浆Hcy的测定采用高效液相色谱荧光检测法，血清叶酸采用放射免疫方法测定。结果 胃黏膜不典型增生患者与正常对照组之间血浆Hcy水平之间的差异有非常显著性(14.74±5.4vs 8.16±3.5mol/L， P<0.001)。胃黏膜不典型增生患者与正常对照组之间血清叶酸水平的差异均有非常显著性(4.29±3.13vs 11.24±4.26 ng/ml，P<0.001)。胃黏膜不典型增生组血清叶酸水平显著低于正常对照组。病理学检查表明：经叶酸补充治疗胃黏膜不典型增生明显改善。结论 胃黏膜不典型增生患者血浆Hcy升高，而血清叶酸水平显著下降。血浆Hcy和血清叶酸水平可能是胃癌的独立的危险因子，其关系值得进一步探讨。

    【关键词】 血浆同型半胱氨酸；血清叶酸；胃黏膜不典型增生；叶酸补充

    Plasma homocysteine and serum folate in patients with gastric dysplasia and the effect of folate supplement

    ZHANG Qin-ying， WANG Yu-ming，ZHENG Jia-ju，et al. The Municiple Hospital of Suzhou(North Part)， Suzhou 215008， China

    【Abstract】 Objective To identify the plasma homocysteine and serum folic acid status in patients with gastric dysplasia and the effect of folate supplement.Methods 29 patients with gastric dysplasia and 25 healthy controls were studied and plasma homocysteine (Hcy) and serum folate were measured. Folate 5mg/day(three months) were given for patients with gastric dysplasia. Results There was significant differences of the plasma Hcy level between patients with gastric dysplasia and healthy controls (14.74±5.4 vs. 8.16±3.5mol/L ......