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血管内皮生长因子和抑癌基因P33ING1与胃癌生物学行为的关系
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血管内皮生长因子类;P33ING1;胃肿瘤;免疫组织化学,,血管内皮生长因子类;P33ING1;胃肿瘤;免疫组织化学,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Relationship of vascular endothelial growth factor and p33ING1 with biological behaviors of gastric carcinoma

    LIANG QiLian, CHEN XiaoDong, WANG SanMing, LI JianWen, ZHENG ZhaoHui, HUANG Bing

    Oncology Center, Affiliated Hospital, Guangdong Medical College, Zhanjiang 524001, China

    【Abstract】 AIM: To study the expressions of vascular endothelial growth factor(VEGF) and P33ING1 in gastric carcinoma, and their relations to the clinicopathological features. METHODS: VEGF protein and P33ING1 protein expressions in 102 cases of human gastric carcinoma tissues and normal tissues around the foci were examined by using immunohistochemistry. RESULTS: The expression of VEGF was high in carcinoma tissues while low in normal tissues(χ2=68.0, P<0.01), as for P33ING1, the patter was contrary(χ2=40.3, P<0.01). The expression of VEGF was related to serosa invasion, TNM stage, lymph node metastasis and 5year survival rate (P<0.05). There was a close relation between the expression of P33ING1 and tumor location, serosa invasion, TNM stage, lymph node metastasis and 5year survival rate (P<0.05). CONCLUSION: VEGF and P33ING are positively correlated with biological behaviors of gastric carcinoma, suggesting that examination by using immunohistochemistry for VEGF and P33ING1 may be of value in making diagnosis, evaluating evolution of disease in patients with gastric carcinoma at the same time. ......

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