妇舒片；_大黄素；_大黄酚；_薄层色谱法；

妇舒片质量标准的研究

http://www.100md.com 《时珍国医国药》 2006年第11期

妇舒片；,大黄素；,大黄酚；,薄层色谱法；,高效液相色谱法,,妇舒片；,大黄素；,大黄酚；,薄层色谱法；,高效液相色谱法,1仪器与试药,2方法与结果,3讨论,参考文献：

     摘要：目的建立妇舒片的质量标准。方法采用薄层色谱法鉴别妇舒片中的大黄、牡丹皮、乌药；并采用高效液相色谱(HPLC)法测定该药中大黄素、大黄酚的含量。结果在薄层色谱中可检测出大黄、牡丹皮、乌药，大黄素在52.2~261.0 μg范围内与峰面积呈良好的线性关系，r=0.999 5，平均加样回收率为98.77%，RSD=1.02%(n=6)；大黄酚在108.1~540.5 μg范围内与峰面积呈良好的线性关系，r=0.999 6，平均加样回收率为99.27%，RSD=1.92%(n=6)。结论所建立的方法简便易行，重现性好，可有效地控制该制剂的质量。

    关键词：妇舒片；大黄素；大黄酚；薄层色谱法；高效液相色谱法

    Study on Quality Standard for Fushu Tablet

    LI Jia，HUANG Jianyou，DENG Zhixu，LONG Jiechao，ZHEN Hanshen

    (Guangxi Institute of TCM,Nanning 530022,China;Guangxi College of TCM,Nanning 530001,China)

    Abstract：ObjectiveTo establish the quality standard of Fushu Tablet.MethodsRadix et Rhizoma Rhei,Cortex Moutan,Radix Linderae in Fushu Tablet were identified by TLC.The content of emodin and chrysophanol in Fushu Tablet was determined by HPLC.ResultsRadix et Rhizoma Rhei,Cortex Moutan,Radix Linderae could be detected by TLC.Emodin showed a good linear relationship at range of 52.2~261.0 μg,r=0.999 5, the average recovery rate was 98.77%,RSD=1.02%(n=6).Chrysophanol showed a good linear relationship at a range of 108.1~540.5 μg,r=0.999 6, the average recovery was 99.27%,RSD=1.92%(n=6).ConclusionThe established method is simple,feasible and reproducible. This study provides a method for the quality control of Fushu Tablet. ......

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