安痛藤；_类风湿性关节炎；_镇痛____

安痛藤对大鼠佐剂性关节炎的实验研究

http://www.100md.com 《时珍国医国药》 2006年第11期

安痛藤；,类风湿性关节炎；,镇痛,,安痛藤；,类风湿性关节炎；,镇痛,1材料,2方法,3结果,4讨论,参考文献：

     摘要：目的研究安痛藤对类风湿性关节炎大鼠的影响，观察其镇痛作用。方法建立福氏佐剂诱导大鼠类风湿性关节炎模型；口服安痛藤水煎液，观察药物对实验性大鼠足肿胀的抑制作用；采用化学刺激致小鼠扭体观察安痛藤的镇痛作用。结果与模型组比较，安痛藤水煎液(2.4 g生药/kg，4.8 g生药/kg)其有明显的镇痛作用，能明显地改善 AA大鼠原发性炎症和继发性炎症，能明显在减轻 AA大鼠的关节肿胀，降低多发性关节炎指数(P<0.01)。结论安痛藤有抗大鼠佐剂性关节炎的作用。

    关键词：安痛藤；类风湿性关节炎；镇痛

    The Effects of Cissus assamica on Adjuvant Arthritis in Rats

    HUANG Liping, XIE Yihui, XIAO Baiquan, ZHANG Yeqing

    (Jiangxi College of Traditional Chinese Medicine,Nangchang 330006,China)

    Abstract：ObjectiveTo study the effect of Cissus assamica on adjuvant arthritis in rats ,as well as its effect on relieving pain.MethodsThe model of adjavant arthritio in rat was induced by intradermal injection of CFA.The parameter of ankle joint was measured at different time points.The inhibitory effects on paw edema of Cissus assamica were observed,and the effects of relieving pain were measured with writhing experiment on mice.ResultsCompared with models,Cissus assamica relieved pain on mice and inhibited paw edema on rats significantly.Primarily and succeeding inflammation were ameliorated.Polyarticular arthritis index decreased.ConclusionCissus assamica has curative effect on AA rats. ......

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