正交设计优选板蓝根蒲公英颗粒制备工艺
喷雾干燥制粒；,颗粒剂；,制备工艺；,正交实验,,喷雾干燥制粒；,颗粒剂；,制备工艺；,正交实验,1仪器与材料,2方法,3结果,4讨论,参考文献：
摘要：目的为提高板蓝根蒲公英颗粒的成品率及提高工作效率，需要筛选制备工艺。方法采用新型喷雾干燥制粒机制粒，以浸膏的提取工艺、进液速度、进出口的风温及辅料的配比为考察因素，每个因素2个水平，以颗粒的成品率为考察指标，采用正交设计法优选出最佳喷雾干燥制备工艺。结果四因素中以辅料的配比及进出口风的温度影响最为明显，其次为进液速度，浸膏的提取工艺影响不大。结论 板蓝根蒲公英颗粒最佳的喷雾干燥工艺条件为蔗糖与糊精的配比为4∶1；进风口的温度为80～90 ℃；出风口的温度为40～50 ℃；进液速度为4；提取液以经过醇沉为佳。关键词：喷雾干燥制粒； 颗粒剂； 制备工艺； 正交实验
Orthogonal Experiments to Select Spray-Drier Technological Preparation for Banlangenpugongying Granules
QU Caihong， MAI Haiyan， JIANG Xianhe, WANG Rongfan
(Department of Pharmacy, The Third Hospital of Sun Yat -sen University, Guangzhou 510630, China)
Abstract：ObjectiveTo raise the end-product and efficiency of Banlangenpugongying Granules, preparation technologies should be screened. MethodsAdopting newly spraying-drier-granulation technology, taking extracting technology, fluid entering speed, temperature of exit and entry, and the matching of accessories as inspecting factors, two levels of each factors, end-product as inspecting marker, we selected the best Banlangenpugongying Granules preparation technology by orthogonal design.ResultsAmong the 4 factors, the matching of accessories and the temperature of exit and entry are the most notable, next is the fluid entering speed, extracting technology is of little importance. ConclusionThe optimum spraying-drier-granulation technology of Banlangenpugongying Granules is A1B1C2D1. ......
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