肺损伤；急性呼吸窘迫综合征；盐酸戊乙奎醚；乙酰胆碱_

盐酸戊乙奎醚在急性肺损伤防治中的应用前景

http://www.100md.com 《创伤外科杂志》 2007年第1期

肺损伤；急性呼吸窘迫综合征；盐酸戊乙奎醚；乙酰胆碱,,肺损伤；急性呼吸窘迫综合征；盐酸戊乙奎醚；乙酰胆碱,关键词：肺损伤；急性呼吸窘迫综合征；盐酸戊乙奎醚；乙酰胆碱,1ALI,ARDS对气道M胆碱能受体的影响,2对非神经性乙酰胆碱系统的影响,3对微循环

     摘要：目前对于急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory dysfunction syndrome,ARDS)的药物治疗策略等方面的研究虽然有了一些进展，但还没有哪种药物能对ALI/ARDS的治疗有根本的改变。抗胆碱药物对急性肺损伤的病情有一定的缓解作用，本文拟根据近些年来抗胆碱药在ALI/ARDS方面的作用，探讨盐酸戊乙奎醚在急性肺损伤预防或治疗中的应用前景。

    关键词：肺损伤；急性呼吸窘迫综合征；盐酸戊乙奎醚；乙酰胆碱

    Potentiality in treatment of acute lung injury with penehyclidine hydrochloride

    YU Chenbin,SUN Haichen

    (Nanjing General Hospital of Nanjing Military Command,School of Medicine,Nanjing University,Nanjing 210002,China)

    Abstract： Although there are many new approaches to treatments for acute lung injury(ALI) or acute respiratory dysfunction syndrome(ARDS) with all kinds of drugs,we have not seen some drug which has a definite effects to healing ALI/ARDS well.Anticholine drugs may have some benefit on treating ALI/ARDS.In this paper,we look up recent progress of anticholinergic therapies and wish indicate that penehyclidine hydrochloride may be a new therapeutic option for ALI/ARDS than other anticholinergic agents which have no relative selectivity for muscarinic receptor subtypes.

    Key words:lung injury；ARDS；penehyclidine hydrochloride；acetylcholine ......

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