谷慷太林；_骨折愈合；_骨密度____

谷慷太林注射液促进大鼠骨折愈合的实验研究

http://www.100md.com 《新疆医科大学学报》 2007年第1期

谷慷太林；,骨折愈合；,骨密度,,谷慷太林；,骨折愈合；,骨密度,关键词:谷慷太林；骨折愈合；骨密度,1材料和方法,2结果,3讨论,参考文献：

     摘要: 目的：探讨骨组织提取的可溶性多肽片段药物谷慷太林注射液对大鼠骨折愈合的影响。方法：将48只SD大鼠制成双侧桡骨闭合性骨折模型，随机分为谷慷太林组和模型对照组，术后24 h开始给药。分别于给药后第7、14、28、42天处死，对其桡骨骨折端行X线摄片观察、骨密度(BMD)测定及组织学观察。结果：X线片示谷慷太林组骨缺损骨小梁多，桥接骨缺损多。谷慷太林组各时段骨密度均高于模型对照组。组织学检查显示谷慷太林组骨性骨痂多，软骨性骨痂少，骨痂改建塑形和临床愈合快，优于模型对照组。结论：谷慷太林注射液具有明显促进骨折愈合的作用。

    关键词: 谷慷太林；骨折愈合；骨密度

    Study on accelerating rat fracture Healing by injection of soluble multipeptides abstracted from bone tissue marked Gu Kang Tai Lin

    WANG Lei，SHI Xiaoli, GAN Ziming， et al

    (Department of Haman Anatomy，Xinjiang Medical University，Urumqi 830054，China)

    Abstract： Objective： To explore the effects of soluble multipeptide agent， marked “Gu Kang Tai Lin”， derived from bone tissue on rat bone fracture healing. Methods： Radius fracture of 48 female rats were produced. Then they were divided randomly into 2 groups： Gu Kang Tai Lin group and Model group. After 24 th hours of operation they were intramuscularly injected medicine. Six rats in each group were killed on the 7, 14, 28, 42 th day after operation to observe the radiographic findings ......

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