神经节苷脂GM1；亚低温；脑缺氧；缺氧缺血性脑损伤；大鼠[中

神经节苷脂GM1与亚低温联合应用对新生鼠缺氧缺血性脑损伤的保护作用

http://www.100md.com 《现代医学》 2007年第1期

神经节苷脂GM1；亚低温；脑缺氧；缺氧缺血性脑损伤；大鼠[中图分类号]R363,,]神经节苷脂GM1；亚低温；脑缺氧；缺氧缺血性脑损伤；大鼠[中图分类号]R363,[关键词]神经节苷脂GM1；亚低温；脑缺氧；缺氧缺血性脑损伤；

     [摘要]目的探讨神经节苷脂GM1与亚低温对新生大鼠缺氧缺血性脑损伤的保护作用。方法用75只新生7d的SD大鼠制作缺氧缺血(HIBD)模型，随机分为假手术(A)组、模型(B)组、神经节苷脂GM1(C)组、亚低温(D)组、神经节苷脂与亚低温联合干预(E)组共5组，每组15只。观察不同干预方法对新生大鼠缺氧缺血后24h脑含水量、神经细胞死亡率及30d后学习和记忆能力的影响。结果 B组脑含水量、神经细胞死亡率显著高于A组，学习、记忆能力显著下降(P<0.05)，各干预组脑含水量、神经细胞死亡率下降，学习、记忆能力显著改善(P<0.05)，而以E组改变更明显(P<0.05)。结论神经节苷脂GM1和(或)亚低温均可显著减轻HI后脑损伤，联合干预保护作用更佳。

     [关键词]神经节苷脂GM1；亚低温；脑缺氧；缺氧缺血性脑损伤；大鼠[中图分类号]R363

    Neuroprotective effects of ganglioside GM1 and mild hypothermia on hypoxicischemic brain damage in neonatal rats

    WANG Haiying,LIU Jiahao,CHAI Binying,TANG Hongli

    (School of Clinical Medicine, Southeast University,Nanjing 210009,China)

    Abstract: Objective To investigate the protective effects of ganglioside GM1 and/or mild hypothermia on hypoxicischemic brain damage in neonatal rats. Methods Seventyfive neonate rats(subjected to unilateral left carotid artery ligation and given 8%oxygen for 2h) were randomly allocated to five groups：sham operation group(A),model group(B),GM1 group(C),hypothermia group(D), GM1 and hypothermia group(E).Changes of brain edema and percentage of dead neurons(HDNP) at 24h and behaviors of learning and memory at 30d after HI insult were investigated. Results Brain edema and HDNP were significantly increased in group B compared with group A,whereas behaviors of learning and memory in group B were reduced significantly. Brain edema,HDNP and behaviors were improved in group C,D and E(P<0.05) ......

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