端粒酶在维吾尔族子宫颈癌与宫颈上皮内瘤样病变中的表达及意义
宫颈癌；,端粒酶；,TRAPPCR,,宫颈癌；,端粒酶；,TRAPPCR,关键词：宫颈癌；端粒酶；TRAPPCR,1材料与方法,2结果,3讨论,参考文献:
摘要: 目的：探讨端粒酶激活与维吾尔族子宫颈癌的关系。方法：应用重复序列扩增(TRAP)法检测32例宫颈癌，25例各级宫颈上皮内瘤变(CIN)，33例慢性宫颈炎组织的端粒酶活性。结果: 端粒酶阳性率依次为：CIN>宫颈癌>慢性宫颈炎(P<0.05)。CINⅢ级>CINⅠ、Ⅱ级，各组之间具有显著性差异(P<0.05)。端粒酶活性水平：CIN>宫颈癌>慢性宫颈炎；CINⅢ级>CINⅠ，Ⅱ级。端粒酶在宫颈癌早期(Ⅰ期，Ⅱ期)及晚期(Ⅲ，Ⅳ期)之间无差异(P<0.05)，在宫颈癌高分化及中低分化组织中的阳性表达及在宫颈鳞癌与腺癌之间的表达无显著性差异(均P<0.05，)。结论：维吾尔族宫颈癌的发生与端粒酶的激活有关，端粒酶激活是宫颈癌发生的早期事件。关键词：宫颈癌； 端粒酶； TRAPPCR
Expression and significance of telomerase activity in cervical cancer and cervical intraepithelial neoplasim in uighur women
Zufeiya·Aili, Lalai·Suzuke
(Department of Gynecology, First Affiliated Hospital Xinjiang Medical University,Urumqi 830054, China)
Abstract: Objective: To study the Expression and significance of telomerase activity in cervical cancer and cervical intraepithelial neoplasim in uighur women. Methods: Telomerase activity was detected by TRAPPCR, in 32 cervical cancer, 25 cervical intraepithelial neoplasia (CIN) and 33 chronic cervicitis cases. Results: With regard to the positive expression rate of telomerase CIN>cervical cancer>chronic cervicitis; CINⅢ>CINⅠ, Ⅱ(P<0.05).There are no significant differens between early stage and late stage, (P<0.05). Positive rate of telomerase in cervical cancer did not correlate with clinical staging, histological grading and histologic subtypes (P<0.05). Conclusion: Reactivation of telomerase is an early event and may play an important role in uighur women during cervical carcinogenesis and progression. ......
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