肿瘤坏死因子α基因启动子区多态性与乙型肝炎病毒感染相关性的荟萃分析
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田国保, 曾 争, 陆海英, 崔建军, 田 地
肿瘤坏死因子a;基因多态性;乙型肝炎病毒;荟萃分析田国保,曾争,陆海英,崔建军,田地.肿瘤坏死因子a基因启动子区多态性与乙型肝炎病毒感染相关性的荟萃分析. 世界华人消化杂志2007;15(6)580-584,田国保,崔建
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田国保, 崔建军, 田地, 北京大学第一医院感染疾病科病毒研究室 北京市 100034
曾争, 陆海英, 北京大学第一医院感染疾病科 北京市 100034国家自然科学基金资助项目, No.30671855
田国保, 北京大学第一医院感染疾病科硕士生, 主要从事与乙型肝炎病毒感染相关的易感基因或拮抗基因的研究.
通讯作者: 曾争, 100034, 北京市, 北京大学第一医院感染疾病科. zeng@bjmu.edu.cn
电话: 010-66551799
收稿日期: 2006-11-13 接受日期: 2006-12-08
A meta-analysis on the relationship between tumor necrosis factor-α promoter polymorphisms and chronic hepatitis B virus infection
Guo-Bao Tian, Zheng Zeng, Hai-Ying Lu, Jian-Jun Cui, Di Tian
Guo-Bao Tian, Jian-Jun Cui, Di Tian, Laboratory of Virology, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Zheng Zeng, Hai-Ying Lu, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Supported by National Natural Science Foundation of China, No. 30671855
Correspondence to: Zheng Zeng, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China. zeng@bjmu.edu.cn
Received: 2006-11-13 Accepted: 2006-12-08
AbstractAIM:To investigate the relationship between the polymorphisms of tumor necrosis factor-a (TNF-a) gene promoter and hepatitis B virus (HBV) infection.
METHODS: A total of 18 case-control studies were indexed from PubMed, Embase and CNKI database, and meta-analysis and meta-regression analysis were performed to explore the relationship between the polymorphisms of TNF-a gene promoter and HBV infection as well as the differences between each study.
RESULTS: The frequency of genotype (TNF-a-308A/G and A/A) was significantly higher in spontaneously recovered group (904 controls) as compared with that in persistent HBV infection group (2303 cases) in Asian population (Mongoloid) (P = 0.001). In European population (Caucasian), the frequency of genotype (TNF-a-238A/G and A/A) was slightly higher in persistent HBV infection group (256 cases) as compared with that in spontaneously recovered group (195 controls) (P = 0.07). The ethnicity, sample size, genotyping procedure and geographical location were the influential factors in the case-control study, and the estimated between-study variance was reduced by 0.236.
CONCLUSION: The presence of the genotype (TNF-a-238A/G and A/A) may be associated with persistent HBV infection, while the genotype (TNF-a-308A/G and A/A) may be associated with HBV clearance. The ethnicity, sample size, genotyping procedure and geographical location are factors influencing the results of case-control study.
Key Words: Tumor necrosis factor-a; Polymorphism; Hepatitis B virus; Meta-analysis
Tian GB, Zeng Z, Lu HY, Cui JJ, Tian D. A meta-analysis on the relationship between tumor necrosis factor-a promoter polymorphisms and chronic hepatitis B virus infection. Shijie Huaren Xiaohua Zazhi 2007;15(6):580-584 ......
田国保, 崔建军, 田地, 北京大学第一医院感染疾病科病毒研究室 北京市 100034
曾争, 陆海英, 北京大学第一医院感染疾病科 北京市 100034国家自然科学基金资助项目, No.30671855
田国保, 北京大学第一医院感染疾病科硕士生, 主要从事与乙型肝炎病毒感染相关的易感基因或拮抗基因的研究.
通讯作者: 曾争, 100034, 北京市, 北京大学第一医院感染疾病科. zeng@bjmu.edu.cn
电话: 010-66551799
收稿日期: 2006-11-13 接受日期: 2006-12-08
A meta-analysis on the relationship between tumor necrosis factor-α promoter polymorphisms and chronic hepatitis B virus infection
Guo-Bao Tian, Zheng Zeng, Hai-Ying Lu, Jian-Jun Cui, Di Tian
Guo-Bao Tian, Jian-Jun Cui, Di Tian, Laboratory of Virology, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Zheng Zeng, Hai-Ying Lu, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Supported by National Natural Science Foundation of China, No. 30671855
Correspondence to: Zheng Zeng, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China. zeng@bjmu.edu.cn
Received: 2006-11-13 Accepted: 2006-12-08
AbstractAIM:To investigate the relationship between the polymorphisms of tumor necrosis factor-a (TNF-a) gene promoter and hepatitis B virus (HBV) infection.
METHODS: A total of 18 case-control studies were indexed from PubMed, Embase and CNKI database, and meta-analysis and meta-regression analysis were performed to explore the relationship between the polymorphisms of TNF-a gene promoter and HBV infection as well as the differences between each study.
RESULTS: The frequency of genotype (TNF-a-308A/G and A/A) was significantly higher in spontaneously recovered group (904 controls) as compared with that in persistent HBV infection group (2303 cases) in Asian population (Mongoloid) (P = 0.001). In European population (Caucasian), the frequency of genotype (TNF-a-238A/G and A/A) was slightly higher in persistent HBV infection group (256 cases) as compared with that in spontaneously recovered group (195 controls) (P = 0.07). The ethnicity, sample size, genotyping procedure and geographical location were the influential factors in the case-control study, and the estimated between-study variance was reduced by 0.236.
CONCLUSION: The presence of the genotype (TNF-a-238A/G and A/A) may be associated with persistent HBV infection, while the genotype (TNF-a-308A/G and A/A) may be associated with HBV clearance. The ethnicity, sample size, genotyping procedure and geographical location are factors influencing the results of case-control study.
Key Words: Tumor necrosis factor-a; Polymorphism; Hepatitis B virus; Meta-analysis
Tian GB, Zeng Z, Lu HY, Cui JJ, Tian D. A meta-analysis on the relationship between tumor necrosis factor-a promoter polymorphisms and chronic hepatitis B virus infection. Shijie Huaren Xiaohua Zazhi 2007;15(6):580-584 ......
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