[摘要] 目的：研究骨质疏松症与血清瘦素和转化生长因子β(TGF-β)浓度的关系。方法：酶联免疫吸附法(ELISA)检测24例骨质疏松症患者血清中瘦素和TGF-β水平，并与正常人对照；计算血清瘦素、TGF-β与骨密度的相关性。结果：骨质疏松症患者TGF-β水平较对照组明显降低(P<0.05)，但血清瘦素与对照组无显著差异(P>0.05)。血清TGF-β与骨密度呈正相关，瘦素与骨密度无相关性。结论：TGF-β水平降低可能是骨质疏松症发病的原因之一，而无直接证据表明瘦素水平变化与骨质疏松症发病有相关性。

    [关键词] 骨质疏松症；瘦素；转化生长因子β；酶联免疫吸附检测

    Relationship Between Osteoporosis and Serum Transforming Growth Factor β and Leptin

    ZHANG Lei,DAI Ji-Bin,SHI Yong-yan,CUI Cao.

    (Faculty of Anatomy and Embryology,School of Medicine,Wuhan University,Wuhan,Hubei 430071;Department of Trauma Orthopaedics,Renmin Hospital,Department of Orthopaedics,Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China)

    Abstract: Objective To explore the relationship between osteoporosis and leptin and transforming growth factor β (TGF-β) levels. Methods Serum leptin and TGF-β in 24 patients with osteoporosis were measured by ELISA, and compared with that in 24 healthy subjects as control. Results The serum TGF-β in the patients with osteoporosis was significantly lower than that in healthy subjects.however,there was no significant difference in serum leptin between patients and healthy subjects.The serum TGF-β was positively correlated with bone mineral density.However,there is not correlation between serum leptin and bone mineral density. Conclusion The decreased level of TGF-β may be one of the causes to precipitate osteoporosis, but there is no direct evidence demonstrating the change of serum leptin is correlated with the pathogonesis of osteoporosis. ......