银杏叶提取物对慢性乙型肝炎患者肝窦微循环障碍的影响
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主余华, 王 京, 梁 斌, 任万华, 张春清
银杏叶提取物;慢性乙型肝炎;肝窦;肝脏微循环,主余华,王京,梁斌,任万华,张春清,通讯作者:,EffectofGinkgobilobaextractonlivermicrocirculatorydysfunctioninpatientswit
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主余华, 王京, 梁斌, 任万华, 张春清, 山东大学山东省立医院消化内科 山东省济南市 250021
山东省科委优秀中青年科学家基金, No. 03BS016
通讯作者: 张春清, 250021, 山东省济南市, 山东省立医院消化内科. zhchqing@medmail.com.cn
电话: 0531-85186350
收稿日期: 2006-12-07 接受日期: 2007-01-04
Effect of Ginkgo biloba extract on liver microcirculatory dysfunction in patients with chronic hepatitis B
Yu-Hua Zhu, Jing Wang, Bin Liang, Wan-Hua Ren, Chun-Qing Zhang
Yu-Hua Zhu, Jing Wang, Bin Liang, Wan-Hua Ren, Chun-Qing Zhang,Department of Gastroenterology, Shandong Provincial Hospital of Shandong University, Ji’nan 250021, Shandong Province, China
Supported bythe Foundation of Shandong Provincial Science and Technology Commission for Excellent Young and Middle-Aged Scientists, No. 03BS016
Correspondence to:Chun-Qing Zhang, Department of Gastroenterology, Shandong Provincial Hospital of Shandong University, Ji’nan 250021, Shandong Province, China. zhchqing@medmail.com.cn
Received:2006-12-07 Accepted:2007-01-04
Abstract
AIM: To evaluate the effect of Ginko biloba extract (EGb761) on the microcirculatory dysfunction of hepatic sinusoid in patients with chronic hepatitis B.
METHODS: Forty-seven chronic hepatitis B patients were randomly divided into EGb761 treatment group (n = 26) and control group (n = 21). All the cases underwent liver biopsy before and after treatment. The pathological changes of liver tissues were detected by HE staining. At the same time, 10 samples were selected from each group, and the changes of hepatic sinusoidal microcirculation were analyzed by electron microscopy before and after treatments.
RESULTS: After treatment, liver cirrhosis and tissue damages were improved significantly (P < 0.05) in EGb761 treatment group (inflammation score: 10.7 ± 4.8; fibrosis score: 8.3 ± 4.2) as compared with those in patients before treatment (inflammation score: 15.7 ± 6.3; fibrosis score: 11.9 ± 6.2) and the controls (inflammation score: 14.2 ± 6.6; fibrosis score: 11.5 ± 5.6). Meanwhile, electron microscopy showed that liver microcirculatory dysfunction was improved obviously in EGb761 group after treatment in comparison with that before treatment, and the congregation of red cells in liver sinus (32 vs 56, P < 0.01), the sedimentation of collagen in hepatic sinusoid and Disse space (23 vs 38, P < 0.05), the damage of hepatic sinusoidal endothelial cells (41 vs 59, P < 0.05), and the hepatic sinusoidal capilarization (17 vs 32, P < 0.05) were markedly alleviated. But no difference was found before and after treatment in control group (P > 0.05).
CONCLUSION: EGb761 can improve hepatic microcirculation possibly through protecting hepatic sinusoidal endothelial cells from injury, inhibiting aggregation of blood cells, collagenous proliferation in sinusoid or Disse space and hepatic sinusoidal capilarization.
Key Words: Ginko biloba extract; Chronic hepatitis B; Hepatic sinusoid; Hepatic microcirculation ......
主余华, 王京, 梁斌, 任万华, 张春清, 山东大学山东省立医院消化内科 山东省济南市 250021
山东省科委优秀中青年科学家基金, No. 03BS016
通讯作者: 张春清, 250021, 山东省济南市, 山东省立医院消化内科. zhchqing@medmail.com.cn
电话: 0531-85186350
收稿日期: 2006-12-07 接受日期: 2007-01-04
Effect of Ginkgo biloba extract on liver microcirculatory dysfunction in patients with chronic hepatitis B
Yu-Hua Zhu, Jing Wang, Bin Liang, Wan-Hua Ren, Chun-Qing Zhang
Yu-Hua Zhu, Jing Wang, Bin Liang, Wan-Hua Ren, Chun-Qing Zhang,Department of Gastroenterology, Shandong Provincial Hospital of Shandong University, Ji’nan 250021, Shandong Province, China
Supported bythe Foundation of Shandong Provincial Science and Technology Commission for Excellent Young and Middle-Aged Scientists, No. 03BS016
Correspondence to:Chun-Qing Zhang, Department of Gastroenterology, Shandong Provincial Hospital of Shandong University, Ji’nan 250021, Shandong Province, China. zhchqing@medmail.com.cn
Received:2006-12-07 Accepted:2007-01-04
Abstract
AIM: To evaluate the effect of Ginko biloba extract (EGb761) on the microcirculatory dysfunction of hepatic sinusoid in patients with chronic hepatitis B.
METHODS: Forty-seven chronic hepatitis B patients were randomly divided into EGb761 treatment group (n = 26) and control group (n = 21). All the cases underwent liver biopsy before and after treatment. The pathological changes of liver tissues were detected by HE staining. At the same time, 10 samples were selected from each group, and the changes of hepatic sinusoidal microcirculation were analyzed by electron microscopy before and after treatments.
RESULTS: After treatment, liver cirrhosis and tissue damages were improved significantly (P < 0.05) in EGb761 treatment group (inflammation score: 10.7 ± 4.8; fibrosis score: 8.3 ± 4.2) as compared with those in patients before treatment (inflammation score: 15.7 ± 6.3; fibrosis score: 11.9 ± 6.2) and the controls (inflammation score: 14.2 ± 6.6; fibrosis score: 11.5 ± 5.6). Meanwhile, electron microscopy showed that liver microcirculatory dysfunction was improved obviously in EGb761 group after treatment in comparison with that before treatment, and the congregation of red cells in liver sinus (32 vs 56, P < 0.01), the sedimentation of collagen in hepatic sinusoid and Disse space (23 vs 38, P < 0.05), the damage of hepatic sinusoidal endothelial cells (41 vs 59, P < 0.05), and the hepatic sinusoidal capilarization (17 vs 32, P < 0.05) were markedly alleviated. But no difference was found before and after treatment in control group (P > 0.05).
CONCLUSION: EGb761 can improve hepatic microcirculation possibly through protecting hepatic sinusoidal endothelial cells from injury, inhibiting aggregation of blood cells, collagenous proliferation in sinusoid or Disse space and hepatic sinusoidal capilarization.
Key Words: Ginko biloba extract; Chronic hepatitis B; Hepatic sinusoid; Hepatic microcirculation ......
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