趋化性细胞因子受体CXCR4在大肠癌的表达及其临床意义
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张孟贤, Kashif Iqbal, 于世英
CXCR4蛋白;大肠癌;微血管密度;预后,张孟贤,于世英,KashifIqbal,通讯作者:,ExpressionofCXCchemokinereceptorCXCR4incolorectalcarcinomaanditscorrel
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张孟贤, 于世英, 华中科技大学同济医学院附属同济医院肿瘤科 湖北省武汉市 430030
Kashif Iqbal, 华中科技大学同济医学院留学生部 湖北省武汉市 430030
通讯作者: 于世英, 430030, 武汉市解放大道1095号同济医院肿瘤科. syyu@tjh.tjmu.edu.cn
电话: 027-83663807
收稿日期: 2006-12-12 接受日期: 2007-01-07
Expression of CXC chemokine receptor CXCR4 in colorectal carcinoma and its correlation with prognosis
Meng-Xian Zhang, Iqbal Kashif, Shi-Ying Yu
Meng-Xian Zhang, Shi-Ying Yu,Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Iqbal Kashif,Foreign Student Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to:Dr. Shi-Ying Yu, Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan 430030, Hubei Province, China. syyu@tjh.tjmu.edu.cn
Received:2006-12-12 Accepted:2007-01-07
Abstract
AIM: To investigate the expression of chemokine receptor CXCR4 in colorectal carcinoma and its correlation with the clinicopathologic characteristics and prognosis.
METHODS: Immunohistochemistry was used to detect the expression of CXCR4 and tumor microvessel density (MVD) in 67 tissue specimens of colorectal carcinoma, and the correlation between the CXCR4 expression and clinicopathologic factors was evaluated.
RESULTS: The positive rate of CXCR4 expression was 56.7% in colorectal carcinoma, which was correlated with lymph node metastasis, clinical staging and MVD as well as the survival of patients, but not with the sex and age of patients, tumor location, T staging, and pathological types. The expression of CXCR4 was 40.6%, 68.2% and 76.9% in cases of N0, N1 and N2 stage, 39.4% and 73.5% in cases of Ⅰ+Ⅱ and Ⅲ stage, respectively. The positive rate of CXCR4 expression was significantly lower in the case with low MVD than that with high MVD (36.4% vs 74.3%, P < 0.01), and the CXCR4-positive case had a higher recurrent or metastatic rate (47.4% vs 24.1%, P < 0.05) and a lower 3-year survival rate (32.6% vs 71.3%, P < 0.05) than the CXCR4-negative one.
CONCLUSION: Positive CXCR4 expression and high tumor MVD are associated with the poor prognosis of patients, and they can be used as potential predictive factors for the recurrence or metastasis of colorectal cancer.
Key Words: Chemokine receptor CXCR4; Colorectal carcinoma; Microvessel density; Prognosis
Zhang MX, Iqbal K, Yu SY. Expression of CXC chemokine receptor CXCR4 in colorectal carcinoma and its correlation with prognosis. Shijie Huaren Xiaohua Zazhi 2007;15(7):772-776
摘要
目的: 探讨趋化性细胞因子受体CXCR4在大肠癌中的表达及其与预后的关系.
方法: 收集67例大肠癌患者手术标本, 采用免疫组织化学方法检测肿瘤组织中CXCR4蛋白的表达和微血管密度, 分析CXCR4的表达水平与临床病理特征和生存的关系.
结果: 大肠癌组织中CXCR4蛋白表达阳性率为56 ......
张孟贤, 于世英, 华中科技大学同济医学院附属同济医院肿瘤科 湖北省武汉市 430030
Kashif Iqbal, 华中科技大学同济医学院留学生部 湖北省武汉市 430030
通讯作者: 于世英, 430030, 武汉市解放大道1095号同济医院肿瘤科. syyu@tjh.tjmu.edu.cn
电话: 027-83663807
收稿日期: 2006-12-12 接受日期: 2007-01-07
Expression of CXC chemokine receptor CXCR4 in colorectal carcinoma and its correlation with prognosis
Meng-Xian Zhang, Iqbal Kashif, Shi-Ying Yu
Meng-Xian Zhang, Shi-Ying Yu,Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Iqbal Kashif,Foreign Student Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to:Dr. Shi-Ying Yu, Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan 430030, Hubei Province, China. syyu@tjh.tjmu.edu.cn
Received:2006-12-12 Accepted:2007-01-07
Abstract
AIM: To investigate the expression of chemokine receptor CXCR4 in colorectal carcinoma and its correlation with the clinicopathologic characteristics and prognosis.
METHODS: Immunohistochemistry was used to detect the expression of CXCR4 and tumor microvessel density (MVD) in 67 tissue specimens of colorectal carcinoma, and the correlation between the CXCR4 expression and clinicopathologic factors was evaluated.
RESULTS: The positive rate of CXCR4 expression was 56.7% in colorectal carcinoma, which was correlated with lymph node metastasis, clinical staging and MVD as well as the survival of patients, but not with the sex and age of patients, tumor location, T staging, and pathological types. The expression of CXCR4 was 40.6%, 68.2% and 76.9% in cases of N0, N1 and N2 stage, 39.4% and 73.5% in cases of Ⅰ+Ⅱ and Ⅲ stage, respectively. The positive rate of CXCR4 expression was significantly lower in the case with low MVD than that with high MVD (36.4% vs 74.3%, P < 0.01), and the CXCR4-positive case had a higher recurrent or metastatic rate (47.4% vs 24.1%, P < 0.05) and a lower 3-year survival rate (32.6% vs 71.3%, P < 0.05) than the CXCR4-negative one.
CONCLUSION: Positive CXCR4 expression and high tumor MVD are associated with the poor prognosis of patients, and they can be used as potential predictive factors for the recurrence or metastasis of colorectal cancer.
Key Words: Chemokine receptor CXCR4; Colorectal carcinoma; Microvessel density; Prognosis
Zhang MX, Iqbal K, Yu SY. Expression of CXC chemokine receptor CXCR4 in colorectal carcinoma and its correlation with prognosis. Shijie Huaren Xiaohua Zazhi 2007;15(7):772-776
摘要
目的: 探讨趋化性细胞因子受体CXCR4在大肠癌中的表达及其与预后的关系.
方法: 收集67例大肠癌患者手术标本, 采用免疫组织化学方法检测肿瘤组织中CXCR4蛋白的表达和微血管密度, 分析CXCR4的表达水平与临床病理特征和生存的关系.
结果: 大肠癌组织中CXCR4蛋白表达阳性率为56 ......
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