肝素酶: 一种新的广谱的肿瘤转移相关抗原在中晚期肿瘤免疫治疗中的作用研究进展
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杨仕明, 汤旭东, 陈 婷, 熊 震, 陈 陵, 蔡永国, 房殿春
肝素酶;肿瘤;免疫治疗,肝素酶:一种新的广谱的肿瘤转移相关抗原在中晚期肿瘤免疫治疗中的作用研究进展,杨仕明,汤旭东,陈婷,熊震,陈陵,蔡永国,房殿春,通讯作者:,电话:,收稿日期:,接受日期:,Heparanase:anewuniversalmetastasis-associatedant
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杨仕明, 汤旭东, 陈婷, 熊震, 陈陵, 蔡永国, 房殿春, 中国人民解放军第三军医大学西南医院全军消化病研究所 重庆市 400038国家自然科学基金资助项目, No.30200123, No.30570841
通讯作者: 杨仕明, 400038, 重庆市, 中国人民解放军第三军医大学西南医院全军消化病研究所. shimingyang@yahoo.com
电话: 023-68765184
收稿日期: 2006-12-21 接受日期: 2007-01-10
Heparanase: a new universal metastasis-associated antigen in the immunotherapy for the advanced cancers
Shi-Ming Yang, Xu-Dong Tang, Ting Chen, Zhen Xiong, Ling Chen, Yong-Guo Cai, Dian-Chun Fang
Shi-Ming Yang, Xu-Dong Tang, Ting Chen, Zhen Xiong, Ling Chen, Yong-Guo Cai, Dian-Chun Fang,Institute of Gastroenterology of Chinese PLA, Southwest Hospital of the Third Military Medical University, Chongqing 400038, China
Supported byNational Natural Science Foundation of China, No.30200123 and No.30570841
Correspondence to: Yang Shi-Ming, Institute of Gastroenterology of Chinese PLA, Southwest Hospital of the Third Military Medical University, Chongqing 400038.
shimingyang@yahoo.com
Received:2006-12-21 Accepted:2007-01-10
AbstractHeparanase (Hpa) was an endo-β-D-glucuronidase that can cleave heparan sulfate proteoglycans (HSPGs) and has been implicated in tumor angiogenesis and metastasis. It has been reported that Hpa was expressed in almost all the advanced tumors, especially in metastatic tumors, and in contrast, down-regulation of Hpa could inhibit the metastasis of tumors. These results indicated that Hpa could serve as a new universal tumor-metastasis-associated antigen in the immunotherapy for the advanced tumors. Development of Hpa vaccine may establish a new method for the treatment of the advanced tumors. In this review, structure and functions of Hpa and its possibility as a new universal antigen in the immunotherapy of the advanced tumors were discussed.
Key Words: Heparanase; Tumor; Immunotherapy
Yang SM, Tang XD, Chen T, Xiong Z, Chen L, Cai YG, Fang DC. Heparanase: a new universal metastasis-associated antigen in the immunotherapy for the advanced cancers. Shijie Huaren Xiaohua Zazhi 2007;15(8):849-854
摘要肝素酶(Hpa)是裂解硫酸乙酰肝素蛋白多糖的唯一酶类, 能破坏细胞外基质及基底膜, 参与肿瘤血管生成, 与肿瘤的侵袭转移密切相关. 目前的研究表明, Hpa在大多数中晚期肿瘤中都有表达, 尤其在转移性肿瘤中强表达, 而Hpa表达的下调可以抑制肿瘤细胞的转移, 提示Hpa可以作为一种广谱的肿瘤转移相关抗原用于中晚期肿瘤的免疫治疗. Hpa疫苗的开发可望为中晚期肿瘤的治疗开辟新的途径. 本文详细综述了Hpa的结构与功能、对肿瘤转移的促进作用及其机制、以及其作为肿瘤转移相关抗原用于中晚期肿瘤免疫治疗的可能性.
关键词: 肝素酶; 肿瘤; 免疫治疗
杨仕明, 汤旭东, 陈婷, 熊震, 陈陵, 蔡永国, 房殿春. 肝素酶：一种新的广谱的肿瘤转移相关抗原在中晚期肿瘤免疫治疗中的作用研究进展. 世界华人消化杂志 2007;15(8):849-854
0 引言
树突状细胞(dendritic cells, DC)是目前发现的体内功能最强的, 也是唯一能激活初始T淋巴细胞(native T cell)的抗原提呈细胞(APC). DC起源于骨髓CD34+细胞, 他能高水平的表达与抗原递呈有关的MHC-Ⅰ类和MHC-Ⅱ类分子, DC细胞摄取肿瘤相关抗原(tumor associated antigen, TAA)后, 呈递给T细胞, 激活相应的CD4+T细胞和CD8+T细胞. DC还可以靠表达的黏附分子与T细胞膜表面的相应配体CD28和CTLA-4的相互作用而活化Th细胞, 使Th细胞产生大量的细胞因子, 进一步调节活化的Th细胞, 以增强机体的细胞免疫和体液免疫功能, 发挥主动免疫的抗肿瘤作用[1]. 将TAA与DC相结合, 通过DC对肿瘤抗原的高效提呈作用激发机体的特异性抗肿瘤免疫反应是肿瘤免疫治疗的一个热门课题 ......
杨仕明, 汤旭东, 陈婷, 熊震, 陈陵, 蔡永国, 房殿春, 中国人民解放军第三军医大学西南医院全军消化病研究所 重庆市 400038国家自然科学基金资助项目, No.30200123, No.30570841
通讯作者: 杨仕明, 400038, 重庆市, 中国人民解放军第三军医大学西南医院全军消化病研究所. shimingyang@yahoo.com
电话: 023-68765184
收稿日期: 2006-12-21 接受日期: 2007-01-10
Heparanase: a new universal metastasis-associated antigen in the immunotherapy for the advanced cancers
Shi-Ming Yang, Xu-Dong Tang, Ting Chen, Zhen Xiong, Ling Chen, Yong-Guo Cai, Dian-Chun Fang
Shi-Ming Yang, Xu-Dong Tang, Ting Chen, Zhen Xiong, Ling Chen, Yong-Guo Cai, Dian-Chun Fang,Institute of Gastroenterology of Chinese PLA, Southwest Hospital of the Third Military Medical University, Chongqing 400038, China
Supported byNational Natural Science Foundation of China, No.30200123 and No.30570841
Correspondence to: Yang Shi-Ming, Institute of Gastroenterology of Chinese PLA, Southwest Hospital of the Third Military Medical University, Chongqing 400038.
shimingyang@yahoo.com
Received:2006-12-21 Accepted:2007-01-10
AbstractHeparanase (Hpa) was an endo-β-D-glucuronidase that can cleave heparan sulfate proteoglycans (HSPGs) and has been implicated in tumor angiogenesis and metastasis. It has been reported that Hpa was expressed in almost all the advanced tumors, especially in metastatic tumors, and in contrast, down-regulation of Hpa could inhibit the metastasis of tumors. These results indicated that Hpa could serve as a new universal tumor-metastasis-associated antigen in the immunotherapy for the advanced tumors. Development of Hpa vaccine may establish a new method for the treatment of the advanced tumors. In this review, structure and functions of Hpa and its possibility as a new universal antigen in the immunotherapy of the advanced tumors were discussed.
Key Words: Heparanase; Tumor; Immunotherapy
Yang SM, Tang XD, Chen T, Xiong Z, Chen L, Cai YG, Fang DC. Heparanase: a new universal metastasis-associated antigen in the immunotherapy for the advanced cancers. Shijie Huaren Xiaohua Zazhi 2007;15(8):849-854
摘要肝素酶(Hpa)是裂解硫酸乙酰肝素蛋白多糖的唯一酶类, 能破坏细胞外基质及基底膜, 参与肿瘤血管生成, 与肿瘤的侵袭转移密切相关. 目前的研究表明, Hpa在大多数中晚期肿瘤中都有表达, 尤其在转移性肿瘤中强表达, 而Hpa表达的下调可以抑制肿瘤细胞的转移, 提示Hpa可以作为一种广谱的肿瘤转移相关抗原用于中晚期肿瘤的免疫治疗. Hpa疫苗的开发可望为中晚期肿瘤的治疗开辟新的途径. 本文详细综述了Hpa的结构与功能、对肿瘤转移的促进作用及其机制、以及其作为肿瘤转移相关抗原用于中晚期肿瘤免疫治疗的可能性.
关键词: 肝素酶; 肿瘤; 免疫治疗
杨仕明, 汤旭东, 陈婷, 熊震, 陈陵, 蔡永国, 房殿春. 肝素酶：一种新的广谱的肿瘤转移相关抗原在中晚期肿瘤免疫治疗中的作用研究进展. 世界华人消化杂志 2007;15(8):849-854
0 引言
树突状细胞(dendritic cells, DC)是目前发现的体内功能最强的, 也是唯一能激活初始T淋巴细胞(native T cell)的抗原提呈细胞(APC). DC起源于骨髓CD34+细胞, 他能高水平的表达与抗原递呈有关的MHC-Ⅰ类和MHC-Ⅱ类分子, DC细胞摄取肿瘤相关抗原(tumor associated antigen, TAA)后, 呈递给T细胞, 激活相应的CD4+T细胞和CD8+T细胞. DC还可以靠表达的黏附分子与T细胞膜表面的相应配体CD28和CTLA-4的相互作用而活化Th细胞, 使Th细胞产生大量的细胞因子, 进一步调节活化的Th细胞, 以增强机体的细胞免疫和体液免疫功能, 发挥主动免疫的抗肿瘤作用[1]. 将TAA与DC相结合, 通过DC对肿瘤抗原的高效提呈作用激发机体的特异性抗肿瘤免疫反应是肿瘤免疫治疗的一个热门课题 ......
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