血浆肾素血管紧张素醛固酮水平对胺碘酮转复房颤患者窦性心律效果的影响
肾素血管紧张素醛固酮系统；胺碘酮；心房颤动,,肾素血管紧张素醛固酮系统；胺碘酮；心房颤动,1资料与方法,2结果,3讨论,参考文献
【摘要】 目的 研究不同肾素、血管紧张素和醛固酮水平对胺碘酮转律效果的影响。方法 对持续性心房颤动患者，在使用胺碘酮转律后，依转律效果分为转律成功组(n=17)和转律未成功组(n=19)，比较两组患者血浆肾素、血管紧张素和醛固酮浓度的不同，进一步分析其浓度水平与左心房大小的相关性。结果 转律成功组患者血浆肾素、血管紧张素和醛固酮水平显著高于转律未成功组(P<0.01，P<0.05，P<0.05)；血浆肾素、血管紧张素和醛固酮水平与左心房直径呈显著正相关(P<0.01)。结论 肾素、血管紧张素和醛固酮系统的激活对心房颤动的发生、维持和终止起重要作用。加用血管紧张素转换酶抑制剂可能改善心房颤动的转律效果。【关键词】 肾素血管紧张素醛固酮系统；胺碘酮；心房颤动
Effect of reninangiotensinaldosterone system on the results of oral amiodarone reversing the sinus rhythm of patients with persistent atrial fibrillation
JIA Xinwei,DI Pifan,CAO Yanxia,et al.
Affiliated Hospital of Hebei University,Baoding,Hebei 071000
【Abstract】 Objective To probe the effect of different concentrations of renin,angiotensin and aldosterone on amiodarones reversing of sinus rhythm in patients with persistent atrial fibrillation.Methods According to the results of amiodarone reversing their sinus rhythm,36 patients with persistent atrial fibrillation were divided into two groups,successful group (n=17) and unsuccessful group (n=19).Serum concentrations of reninangiotensinaldosterone of the two groups were compared and their correlations with left atrium diameter were also studied.Results The concentrations of renin, angiotensin and aldosterone in successful group were significantly higher than those of unsuccessful group (P<0.001,P<0.05,and P<0.05 respectively).The concentrations of renin,angiotensin and aldosterone correlated significantly with the diameter of left atrium (P<0.01).Conclusion Our results indicate that reninangiotensinaldosterone system plays an important role in the initiation,maintenance and termination of atrial fibrillation.Our results also suggest that angiotensinconverting enzyme inhibitors might facilitate rebuilding of the sinus rhythm for patients with persistent atrial fibrillation. ......
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