穿琥宁注射液在输液中与常用药物配伍的稳定性考察
穿琥宁；配伍变化；稳定性,,],穿琥宁；配伍变化；稳定性,[关键词]穿琥宁；配伍变化；稳定性,1仪器与试药,2方法,3结果,4结论,参考文献：
[摘要] 目的：研究穿琥宁注射液与11种药物配伍的稳定性。方法：考察穿琥宁与11种药物在(20±3)℃和(38±1)℃两种温度条件下6 h内配伍液的外观、pH值、微粒数和紫外吸收度。结果：在上述条件下，穿琥宁注射液与维生素B6、盐酸克林霉素、维生素C配伍后外观、性状、紫外吸收度发生变化，与琥珀酸氢化可的松、地塞米松、利巴韦林、甲硝唑、青霉素钠、头孢哌酮钠、头孢呋辛钠、头孢噻肟钠配伍后外观、微粒、pH值及紫外吸收度无显著变化。结论：穿琥宁注射液不宜与维生素B6、维生素C、盐酸克林霉素配伍，可与其他8种药物配伍使用。[关键词] 穿琥宁；配伍变化；稳定性
An observation on the stability of compatibility of kalii dehydrographolidi succinas injection with other eleven drugs in transfusion
MENG Yongqin, ZHU Zengyan, ZHOU Peipei
(Children's Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215003, China)
[Abstract] Objective:To investigated the stability of compatibility of kalii dehydrographolidi succinas injection with other 11 drugs. Methods: Under (20±3) ℃ and (38±1) ℃, the solutions of kalii dehydrographolidi succinas injection mixed with other eleven drugs were observed within 6 hrs, in their aspect, pH value, particulate counter for injection, UV absorbency and displace of peak. Results: The aspect, pH value, particulate counter and UV absorbency of the compound medicines of kalii dehydrographolidi succinas injection matched with vitamin B6, vitamin C and clindamycin hydrochloride had change, but while matched with hydrocortisone sodium succinate, dexamethasone, ribavirin, medronidazole, penicillin sodium, cefoperazone sodium, cefuroxime sodium, cefotaxime sodium there were no significant change. Conclusions: Kalii dehydrographolidi succinas injection could not be combined with vitamin B6, vitamin C and clindamycin hydrochloride, but could be combined with other eight drugs. ......
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