IL6、IL8、IL10、TNF在多发伤的表达及与预后的相关性研究
白介素6；白介素8；白介素10；肿瘤坏死因子；多发伤,,白介素6；白介素8；白介素10；肿瘤坏死因子；多发伤,1资料与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨血清炎性因子白介素6(IL6)、白介素8(IL8)、白介素10(IL10)及肿瘤坏死因子(TNF)在多发伤中所起的作用。方法 多发伤、单发伤各20例，20例健康者作为正常对照组，分别在住院第1、3、5、7、9天用放射免疫方法检测IL6、 IL8、IL10及TNF。结果 多发伤患者血清中IL6、IL8、及TNF均明显升高，在伤后3～5 d为高峰，5 d后开始降低，多发伤组与其他两组相比差异非常显著(P<0.01)，而单发伤组峰值较低，为一过性。多发伤患者血清中IL10在伤后72 h达高峰，第6～7天逐渐降低，各组相比差异非常显著(P<0.01)。结论 IL6、IL8、TNF属促炎性细胞因子，IL10属抗炎性细胞因子，在多发伤的病情演变中都起着重要的作用，创伤发生后3～5 d是治疗的关键，及时监测IL6、IL8、IL10、TNF的变化，同时监测生命体征、多项生化指标，可更敏感地观察多发伤患者的治疗效果，预测病情发展。【关键词】 白介素6；白介素8；白介素10；肿瘤坏死因子；多发伤
The study of correlation between expression and prognosis of IL6，IL8,IL10 and TNF in the multiple injury
YAO Jingman,YING Lu,XIAO Lei,et al.
Department of Surgery,Tianjin Hospital,Tianjin 300211
【Abstract】 Objective To investigate the effect of inflammatory cytokines interleukin6 (IL6),interleukin8 (IL8),interleukin10 (IL10) and tumornecrosis factor (TNF) in multiple injury.Methods Multiple injury (20 cases),single injury (20 cases),controls (20 healthy cases) were detected for IL6,IL8,IL10,TNF in serum at 1,3,5,7 and 9 day respectively by radioimmunoassay.Results IL6,IL8 and TNF in serum of multiple injury patient increased significantly, the crest was 3～5 d later after trauma,and decreasing 5 days later,the difference among the groups was significant (P<0.01),the peak value in single injury group was low and transient.IL10 in serum of multiple trauma patient attained the high level at 72 h after the trauma,and decreased gradually at 6～7 d,the difference was significant (P<0.01).Conclusion IL6,IL8 and TNF are proinflammatory cytokines,IL10 is antiinflammatory cytokine,they play an important role in the development of diseases,it is the key time of treatment at 1～5 d after trauma.Monitoring IL6,IL8,IL10,TNF in serum in time, and monitoring life sign,biochemical parameters at the same time could sensitively observe the effect of treatment and forecast the trend of diseases in multiple injury patients. ......
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