粒巨噬细胞集落刺激因子；降钙素；钙；大鼠_

粒巨噬细胞集落刺激因子对大鼠降钙素水平的影响

http://www.100md.com 《西安交通大学学报》 2007年第1期

粒巨噬细胞集落刺激因子；降钙素；钙；大鼠,,粒巨噬细胞集落刺激因子；降钙素；钙；大鼠,1对象与方法,2结果,3讨论,参考文献：

     摘要：目的探讨粒巨噬细胞集落刺激因子(GMCSF)对大鼠降钙素水平的影响。方法给动物腹腔注射不同剂量的GMCSF，然后用RIA试剂盒检测血中降钙素水平，同时测血中钙、磷及碱性磷酸酶。结果血清钙水平各实验组均比对照组降低，但仅大剂量组与对照组间差异有统计学意义(P<0.05)；雌性大鼠血清降钙素水平各实验组均比对照组明显降低(P<0.05)；实验组的血清磷均比对照组升高，但无统计学意义(P>0.05)；血清碱性磷酸酶未见有显著的组间差异。结论 50μg/kg的GMCSF可以引起SD大鼠血清钙下降；10μg/kg和50μg/kg的GMCSF均可以引起雌性大鼠的血清降钙素降低，但对血磷、血清碱性磷酸酶无显著影响。

    关键词：粒巨噬细胞集落刺激因子；降钙素；钙；大鼠

    The effect of granulocytemacrophage colonystimulating factor on rat calcitonin

    Dai Guangrong, Zhang Yongli, Shi Bingyin

    (Department of Endocrinology, the First Affiliated Hospital, Medical School of Xian Jiaotong University, Xian 710061, China)

    ABSTRACT: Objective To investigate the effect of granulocytemacrophage colonystimulating factor(GMCSF) on rat calcitonin (CT ). Methods A total of 48 SD healthy rats were randomly divided into control group, low GMCSF (10μg/kg·d) and high GMCSF dosage (50μg/kg·d) groups. The rats in experimental groups were continuously treated by an intraperitoneal application of GMCSF for over 7 days. The level of calcitonin was measured by radioimmunoassay(RIA), and the serum calcium (Ca), ALP and phosphorus(P) were examined by biochemical method. Results The level of the serum calcium in highdosage GMCSF group was lower than that in the control group (P<0.05); the level of the serum calcitonin in the low and highdosage GMCSF treated female rats was lower than that in the control group (P<0.05); the level of the serum phosphorus(P)in the experimental group was higher than that in the control group(P>0.05). Conclusion The high dosage GMCSF can decrease the serum calcium; the low and highdosage GMCSF can decrease the serum calcitonin, but has no effect on the level of serum phosphorus and ALP. ......

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