【摘 要】 目的 探讨内皮素受体拮抗剂益米乐对糖尿病大鼠肾脏病变的保护机制。 方法 选择健康雄性Wistar大鼠42只，随机分为正常对照组(N组)、糖尿病模型组(D组)、益米乐治疗组(Y组)3组，每组14只。D组在大鼠腹腔注射链脲佐菌素建立糖尿病动物模型，Y组在建立糖尿病模型后，给予益米乐注射液50mg·kg -1 ·d-1 ，N组和D组肌注等量的生理盐水。实验4周、8周后，取大鼠的尿、血、肾组织标本，行生化及PCR检测。 结果 3组间大鼠体重、肾重.体重、血压、血糖、24小时尿蛋白定量、血肌酐、尿素氮差异均有显著意义(P<0.05或P<0.01)。肾组织降钙素基因相关肽(CGRP)和内皮素(ET)的mRNA表达差异有显著意义(P<0.05)。 结论 益米乐通过抑制ET-1的分泌，促进CGRP的合成，从而减轻CGRP与ET的失衡，对糖尿病肾病有明确的保护作用。

    【关键词】 糖尿病肾病;降钙素基因相关肽;内皮素;益米乐;大鼠

    The protection effect of Yimile—an antagonist of endothelin receptor on the kidney of diabetic rats HE Wei

    * ，LI Ying，HU Zhijuan，et al.

    * Department of Internal Medicine，Hebei Provincial People's Hospital，Shiji-azhuang 050051，China

    【Abstract】 Objective To investigate the protection mechanism of Yimile which is an antagonist of endothelin(ET)receptor on the Wistar rats with diabetic nephropathy.Methods 42healthy male Wistar rats were randomly di-vided into three groups，normal group，diabetic model group and treatment group，14rats in each group.The diabetic model was made by injecting STZ into the abdomen of rats.The rats in treatment group were given with Yimile injection50mg·kg -1 ·d -1 .The rats in normal group and diabetic model group were injected with equal quantity NS.On the4th and8th week after experiment ......