糖皮质激素;_脑脊髓炎_自身免疫性_实验性;

糖皮质激素在实验性变态反应性脑脊髓炎中对调节性T细胞的作用

http://www.100md.com 《第四军医大学学报》 2000年第5期

糖皮质激素;,脑脊髓炎,自身免疫性,实验性;,T细胞;,FOXP3;,IL10,,糖皮质激素;,脑脊髓炎,自身免疫性,实验性;,T细胞;,FOXP3;,IL10,【关键词】糖皮质激素;脑脊髓炎,自身免疫性,实验性;T细胞;FOXP

     Effect of glucocorticoid on CD4+CD25+ regulatory T cells in mice with experimental autoimmune encephalomyelitis

    LIU Gao, WANG QuanLi, ZHOU Yong

    Ninth Institute, Military Academy of Medical Science, Beijing 100053, China

    【Abstract】 AIM: To investigate the modification by glucocorticoid on CD4+CD25+ regulatory T cells in mice with experimental autoimmune encephalomyelitis (EAE). METHODS: Glucocorticoid or placebo (control group) was injected into Balb/c mice that had been immunized with bovine myelin basic protein (MBP) extracted from the fresh spinal cord of OX. CD4+CD25+ regulatory T cell specific FOXP3 and blood IL10 were evaluated with flow cytometry and ELISA, respectively. RESULTS: Compared with the control group, less EAE symptoms were found in the glucocorticoidinjected group, and the levels of FOXP3 and blood IL10 were statistically different from those in the control group. CONCLUSION: Glucocorticoid can relieve the symptoms of EAE by increasing regulatory T cells and their activities, which offers a potential theoretic basis for its clinical application. ......

百拇医药网 http://www.100md.com/html/DirDu/2007/04/04/41/15/21.htm

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