通心络；冠脉综合征_急性；C反应蛋白；黏附分子_

通心络对急性冠状动脉综合征患者血浆黏附分子的影响

http://www.100md.com 《疑难病杂志》 2007年第3期

通心络；冠脉综合征,急性；C反应蛋白；黏附分子,,通心络；冠脉综合征，急性；C反应蛋白；黏附分子,1资料与方法,2结果,3讨论

     【摘要】目的探讨通心络胶囊对急性冠脉综合征(ACS)患者血浆黏附分子的影响。方法 100例ACS患者随机分为常规治疗组和通心络治疗组(常规治疗+通心络胶囊)，观察治疗前及第7、14 d血浆C反应蛋白(CRP)、可溶性细胞间黏附分子1(sICAM1)、可溶性血管细胞黏附分子1(sVCAM1)的变化。结果与治疗前相比，第7、14 d通心络组血浆CRP、sICAM1和sVCAM1水平均有显著下降(P<0.05或P<0.01)，而常规治疗组仅第14 d有显著变化(P<0.05)。通心络组CRP、sICAM1和sVCAM1水平均显著低于常规治疗组(P<0.01)。结论通心络可能通过抑制可溶性细胞黏附分子、减少血管内膜的炎症反应等途径改善血管内皮功能，从而达到对血管内皮的保护作用。

    【关键词】通心络；冠脉综合征，急性；C反应蛋白；黏附分子

    The effect of Tongxinluo capsule on the plasma adhesion molecule in patients with acute coronary syndrome DENG Jiaqiang,ZHONG Guoqiang,WEI Jinru,et al.First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China

    【Abstract】 Objective To investigate the effect of Tongxinluo on the plasma adhesion molecule in acute coronary syndrome (ACS) patients. Methods 100 patients with ACS were ranolomly divided into conventional therapy group and treatment group(conventional therapy+Tongxinluo gelatin capsule) to observe the change of Creactive protein(CRP),soluble intercellular adhesion molecule1 (sICAM1) and soluble vascular cell adhesion molecule1 (sVCAM1) at first day,7th and 14th day. Results In treatment group, CRP,sICAM1 and sVCAM1 were significant decreased at 7th and 14th day(P<0.05 or P<0.01).There was significant decrease only at the 14th day (P<0.05)in conventional therapy group.Conclusion Tongxinluo capsule has proteetive effect on blood vessel endothelium. ......

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