抗病毒药；_耐药性；_耐药机制____

抗病毒药物耐药及耐药机制研究进展

http://www.100md.com 《中国抗生素杂志》 2006年第2期

抗病毒药；,耐药性；,耐药机制,,抗病毒药；,耐药性；,耐药机制,1抗艾滋病药,2抗乙型肝炎病毒(HBV)药,3抗流感病毒药,4抗疱疹病毒(HSV)药,5如何预防耐药突变,参考文献

     摘要：目前临床应用的抗病毒药物达40多种，为病毒引起的疾病的治疗发挥了重大作用。与临床其他抗感染药物一样，抗病毒药物长期应用易产生耐药性，降低疗效，成为临床治疗及新药开发的重要问题。本文就抗艾滋病毒药物、抗乙型肝炎病毒药物、抗流感病毒药物及抗疱疹病毒药物耐药性及耐药机制研究进行综述。

    关键词：抗病毒药；耐药性；耐药机制

    Advances in antiviral drug resistance and resistance mechanisms

    Tao Peizhen

    (Institute of Medicinal Biotechnology, Peking Union Medical College,Chinese Academy of Medical Sciences, Beijing 100050)

    ABSTRACT There are more than 40 antivirus drugs in the clinical use, which have played very important role in the treatment of viral diseases. Like other kind of antiinfection drugs, antivirus drugs can also induce resistance in longtime use that results the reducing of therapeutic efficacy and becoming a very tough problem in the clinical treatment and the development of new drugs. This paper briefly reviewed the recent advances in resistance and resistance mechanisms of antiHIV drugs, antiHBV drugs, antiinfluenza drugs and antiHSV drugs.

    KEY WORDS Antivirus drugs; Resistance; Resistance mechanisms

    病毒性传染病居传染病之首(占60%以上)，发病率高、传播快，对人类健康形成莫大的威胁。如艾滋病(AIDS)、重症急性呼吸系统综合征(SARS)，各种病毒性肝炎、流行性出血热、流感、感冒、婴幼儿病毒性肺炎、成人腹泻、病毒性心肌炎等等 ......

百拇医药网 http://www.100md.com/html/DirDu/2007/04/28/42/84/82.htm

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