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陶佩珍
抗病毒药；,耐药性；,耐药机制,,抗病毒药；,耐药性；,耐药机制,1抗艾滋病药,2抗乙型肝炎病毒(HBV)药,3抗流感病毒药,4抗疱疹病毒(HSV)药,5如何预防耐药突变,参考文献
摘要： 目前临床应用的抗病毒药物达40多种，为病毒引起的疾病的治疗发挥了重大作用。与临床其他抗感染药物一样，抗病毒药物长期应用易产生耐药性，降低疗效，成为临床治疗及新药开发的重要问题。本文就抗艾滋病毒药物、抗乙型肝炎病毒药物、抗流感病毒药物及抗疱疹病毒药物耐药性及耐药机制研究进行综述。
关键词： 抗病毒药； 耐药性； 耐药机制
Advances in antiviral drug resistance and resistance mechanisms
Tao Peizhen
(Institute of Medicinal Biotechnology, Peking Union Medical College,Chinese Academy of Medical Sciences, Beijing 100050)
ABSTRACT There are more than 40 antivirus drugs in the clinical use, which have played very important role in the treatment of viral diseases. Like other kind of antiinfection drugs, antivirus drugs can also induce resistance in longtime use that results the reducing of therapeutic efficacy and becoming a very tough problem in the clinical treatment and the development of new drugs. This paper briefly reviewed the recent advances in resistance and resistance mechanisms of antiHIV drugs, antiHBV drugs, antiinfluenza drugs and antiHSV drugs. ......
关键词： 抗病毒药； 耐药性； 耐药机制
Advances in antiviral drug resistance and resistance mechanisms
Tao Peizhen
(Institute of Medicinal Biotechnology, Peking Union Medical College,Chinese Academy of Medical Sciences, Beijing 100050)
ABSTRACT There are more than 40 antivirus drugs in the clinical use, which have played very important role in the treatment of viral diseases. Like other kind of antiinfection drugs, antivirus drugs can also induce resistance in longtime use that results the reducing of therapeutic efficacy and becoming a very tough problem in the clinical treatment and the development of new drugs. This paper briefly reviewed the recent advances in resistance and resistance mechanisms of antiHIV drugs, antiHBV drugs, antiinfluenza drugs and antiHSV drugs. ......