氟西汀治疗持续性躯体形式疼痛障碍疗效观察
躯体形式；疼痛障碍；抑郁；氟西汀,,躯体形式；疼痛障碍；抑郁；氟西汀,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨氟西汀治疗持续性躯体形式疼痛障碍的疗效及安全性。 方法 对62例持续性躯体形式疼痛障碍患者应用氟西汀20 mg·d-1治疗，观察6 w。采用疼痛量表、汉密顿抑郁量表、药物副反应量表评定临床疗效及不良反应。 结果 治疗2 w,4 w,6 w末疼痛量表、汉密顿抑郁量表总分及各因子分均较治疗前显著下降(P均<0.01)；治疗疼痛及抑郁症状的有效率均随治疗时间延长而增加，治疗6 w末，有效率分别达75.8%和79.0%。 结论 氟西汀治疗持续性躯体形式疼痛障碍疗效显著，安全性高，依从性好。【关键词】 躯体形式；疼痛障碍；抑郁；氟西汀
Curative effects of fluoxetine in persistent somatoform pain disorder
Sun Meiling ,Wang Yongxue ,Zhang Jian
(Zhumadian Mental Hospital, Zhumadian 463000, Henan, China)
【Abstract】 Objective To explore the curative effects and safety of fluoxetine in persistent somatoform pain disorder. Methods 62 patients with persistent somatoform pain disorder were treated with fluoxetine hydrochloride 20mg/d for 6 weeks. The clinical efficacy was assessed with the Medical Outcomes Study Pain Measures (MOSPM) and Hamilton Depression Scale (HAMD),and adverse effects with Treatment Emergent Symptom Scale (TESS) .Results At the ends of the 2nd,4th and 6th week, total and factors’ scores of both the MOSPM and HAMD notably decreased compared with pretreatment(all P<0.01);effective rates of treating pain and depressive symptoms increased following the prolongation of therapy time, and at the end of 6th week were 76.8% and 79.0% respectively. Conclusion Fluoxetine hydrochloride has notable efficacy, higher safety and better compliance in the treatment of persistent somatoform pain disorder. ......
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