【摘要】 目的 探讨维生素B6在万拉法新维持治疗抑郁症中的辅助治疗作用。 方法 将60例抑郁症患者随机分为两组各30例，两组均给予万拉法新治疗，研究组在原治疗基础上联合维生素B6治疗，疗程12 w。于治疗前及治疗2 w，4 w，6 w，12 w末采用汉密顿抑郁量表和副反应量表评定临床疗效和不良反应。结果 两组治疗6 w末疗效相当(P>0.05)；12 w末研究组汉密顿抑郁量表评分较对照组下降显著(P<0.05)，副反应量表评分差异无显著性(P>0.05)。结论 万拉法新联合维生素B6维持治疗抑郁症较单用万拉发新疗效显著。

    【关键词】 维生素B6；万拉法新；抑郁症；汉密顿抑郁量表；副反应量表

    A control study of combination of venlafaxine and vitamin B6 in the treatment of depression

    Jie Rui, Wang Gangping, Feng Xiaoping

    (Tianshui Mental Hospital, 741000,Gansu，China)

    【Abstract】 Objective To explore the adjunctive therapeutic action of vitamin B6 to venlafaxine in the maintenance therapy of depression. Methods 60 patients were randomly divided into research group (n=30, took venlafaxine and vitamin B6) and control group (n=30,did single venlafaxine) for 12 weeks. Curative effects were assessed with the Hamilton Depression Scale (HAMD) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) before treatment and at the ends of 2nd, 4th, 6th and 12th week treatment, respectively. Results At the end of the 6th week, the curative effects of the 2 groups were equivalent(P>0.05); at the end of 12th week, score of the HAMD decreased more significantly in the research than in the control group(P<0.05), and there was no difference in the TESS between the 2 groups(P>0.05). Conclusion Venlafaxine combined with vitamin B6 is better than single venlafaxine in the maintenance therapy of depression. ......