Expressions of MMPª²7, MVD in colorectal carcinoma and their correlations with metastasis

    GUO Baoª²Wen1£¬ LI Qiª²Jia2£¬ YANG Lin1£¬ WU Minª²Lan1£¬ ZHENG Baoª²Jun1£¬ KAN Deª²Xin3

    1Department of General Surgery, Workers¬ð Hospital, Tangshan 063000, China, 2Experimental Center, North China Coal Medical College, Tangshan 063000, China, 3Qian¬ðan Hospital of Traditional Chinese Medicine, Qian¬ðan 064400, China

    ¡¾Abstract¡¿ AIM: To investigate the relationship among matrix metalloproteinaseª²7 (MMPª²7), microvessel density (MVD) and clinicopathology in colorectal carcinoma and their roles in tumor invasion and metastasis. METHODS: Immunohistochemical (SP) method was performed to detect the expressions of MMPª²7 and MVD in biopsy specimens of the colorectal carcinoma (n=55) and of the healthy controls (n=20). RESULTS: Immunohistochemical staining revealed that the positive rate of MMPª²7 protein was 67.3% in colorectal carcinoma and 30.0% in controls (P<0.05); the expression of MVD was 41.32¡À6.39 in the colorectal carcinoma and 24.17¡À6.23 in controls (P<0.05). There was significant difference in the expression of MMPª²7 between in Dukes¬ð stage A, B (65.85%) and stage C, D(92.86%) of carcinoma (P<0.05). In the meanwhile, MVD was 35.22¡À7.37 in stage A, B and 43.67¡À4.34 in stage C, D(P<0.05). The expression of MVD in MMPª²7 positive group was significantly higher than that in MMPª²7 negative group (P<0.05). CONCLUSION: The overpressions of MMPª²7 and MVD may be helpful for intratumoral angiogenesis and metastasis of colorectal carcinoma. MMPª²7 and MVD provide a new valuable indictor for predicting early the highª²risk patients. ......