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    中华医学杂志920138 Estimation of serum creatine kinase MM isoforms in assessing reperfusion after acute myocardial infarction Yang Zhenhua. et al. Beijing Hospital,100730

    Creatine kinase(CK),aspartate aminotransferase(AST),a-hydroxybutyrate dehydrogenase(HBDH),lactate dehydrogenase(LD)and LD isoforms were measured in 17 acute myocardial infarction(AMI)patients treated with thrombolysis resulting in reperfusion and 2 not resulting in reperfusion as well as 71 treated conventionally to assess reperfusion. The results showed that the peak of the ratio of MM3 to MM1 was attained significantly earlier in patients with reperfusion than in those conventionally treated and those without reperfusion, and this ratio is considered to be a good indicator to assess reperfusion. The results were similar to those of previous reports. The peak in all th 17 patients with confirmed reperfusion was attained within 9 hours after onset of AMI, while only 9 of the 73 patients in the group without reperfusion had their peaks within 9 hours. The diagnostic efficiency was 94%. The authors suggested a new indicator for assess reperfusion. An increase of CK-MM3 over 10% from the first to the second hour after treatment with ruokinase wsa found in 15 of the 17 urokinase-treated patients with reperfusion. The diagnostic efficiency was also 94%. We consider that it is an indicato ras good as the peak of ratio of MM3/MM1. Furthermore, with this indicator, it is possible to assess reperfusion in two hours after treatment with urokinase. ......

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