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    中华医学杂志930337 Serum anti-hepatitis C virus and hepatitis C virus RNA in patients with hepatocellular carcinoma Jiang Minde,ct al.Department of Gastroenterology,General Hospi-tal of Chengdu Command,Chengdu 610083.

    Serum anti-HCV and HCV RNA (RT-PCR),possible association to the marders of hepatitis B verus (HBV-M) including HBsAg were evaluated in 48 pa-tients with hepatocellular carcinoma (HCC).The re-sults indicated that 13 were anti-HCV positive in HCC group and 5 in other cancers (control group,p<0.05).Serum HCV RNA was detected in 11 pa-tients with HCC(23%).The positive rate of HCV RNA and/or anti-HCV(HCV-M)was 38% in all HCC cases,80%(12/15)in HBV-M (-)HCC,58%(14/24) in HBsAg(-),18%(6/33) in HBV-M(+),and 15%(4/24)in HBsAg(+).HBV-M and/or HCV-M was found positive in 45 patients with HCC(93.8%).Our study shows that both HBV and HCV in fections are related to the development of HCC.HCV-M was found positive mostly in HBV-M negative HCC patients and serum HCV RNA replication existed in soem of HCC cases.

    Key wods Hepatoma Hepatitis C virus Ribonucleic acid,hepatitis Cvirus Polymerase chain reaction ......

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