大川芎丸抗血小板聚集作用
作者：尤越人 雷天落 马涛 匡荣 杨亮
单位：沈阳药科大学药学系， 沈阳 110015
关键词：大川芎丸；血栓；血小板聚集
沈阳药科大学学报990221 摘 要 大川芎丸水煎液对ADP诱导的家兔、大白鼠、小白鼠体内血小板聚集有明显的抑制作用.大川芎丸水煎液4.5 g/kg具有抑制家兔血栓形成的作用.
分类号 R96
Effects of Da Chuanxiong Pills on Platelet Aggregation
You Yueren,Lei Tianluo,Ma Tao,Kuang Rong,Yang Liang
, http://www.100md.com
Department of Pharmacy,Shenyang Pharmaceutical University, Shenyang 110015
Abstract The effects of Da Chuanxiong Pills(DCXP)on thrombosis were studied.Formation of thrombosis and platelet aggregation induced by ADP were inhibited in rabbits by taking orally 4.5 g/kg of the boiling water decoction(TBWE) of DCXP.The platelet aggregation induced by ADP were inhibited by taking orally 1,2 g/kg of TBWE in rats and 40,60 g/kg in mice,respectively.
, 百拇医药
Key words Da Chuanxiong Pills :thrombosis;platelet aggregation
大川芎丸为我国传统中药方，民间用于治疗“偏正头痛”、“首风眩晕”，我国历代本草均有述及〔1〕.作者初步探讨了大川芎丸的抗血栓及抗血小板聚集作用.
1 实验方法与结果
1.1 对家兔血栓形成的影响
取雄性家兔，用颈动脉穿线法形成血栓，4 h后取出血栓，计算湿重与体重之比.结果见表1.大川芎丸水煎液4.5 g/kg具有抑制血栓形成的作用.
1.2 对ADP诱导的家兔血小板聚集的影响
取雄性家兔，按表2分组给药.给药后3 h常规方法测定血小板聚集率，结果见表2.大川芎丸水煎液能明显抑制ADP诱导的家兔体内血小板聚集.
, http://www.100md.com
Tab.1 Effect of TBWE on thrombosis in rabbits Group
Dosage/
g.kg-1
n
Thrombosis weight/
rabbit weight
(
±s)/mg.kg-1
Inhibition/
, 百拇医药
%
NS
8
16.2±5.2
TBWE
2.3
8
14.8±4.7
8.6
4.5
9
11.6±2.5*
28.4
, http://www.100md.com
Compared with NS *P<0.05Tab.2 Effect of TBWE on rabbit platelet aggregation induced by ADP in vivo Group
Dosage/g.kg-1
n
Agg/
±s,%
Inhibition/%
NS
6
46.2±8.1
, http://www.100md.com
TBWE
4\^5
6
18.7±5.6**
59.5
Compared with NS **P<0.01
1.3 对ADP诱导的大白鼠血小板聚集的影响
取雄性大白鼠，按表3分组给药，分别于给药前和给药后1 h依常规方法测定血小板聚集率，结果见表3.大川芎丸水煎液能明显抑制ADP诱导的大白鼠体内血小板聚集.
Tab.3 Effect of TBWE on rat platelet aggregation induced by ADP in vivo Group
, http://www.100md.com
Dosage/
g.kg-1
n
Agg/
±s,%
Inhibition/%
0
1
NS
6
49.8±13.7
57.0±4.9
, http://www.100md.com
TBWE
1
6
47.8±8.1
34.9±8.5**
38.8
2
6
53.1±15.0
33.1±8.4
41.9
Compared with NS **P<0.01Tab.4 Effect of TBWE on mice platelet aggregation induced by ADP in vivo Group
, 百拇医药
Dosage/g.kg-1
n
Agg/
±s,%
Inhibition/%
NS
10
44.5±7.4
TBWE
40
8
, http://www.100md.com 24.3±12.5**
40.7
60
8
17.7±7.7**
59.5
Compared with NS **P<0.01
1.4 对ADP诱导的小白鼠血小板聚集的影响
取雄性小白鼠，按表4分组给药，于给药后1 h取血依常规方法测定血小板聚集率，结果见表4.大川芎丸水煎液具有抗ADP诱导的小白鼠体内血小板聚集作用.
2 结论
大川芎丸水煎液抑制ADP诱导的家兔及大、小鼠体内血小板聚集，并抑制家兔血栓形成.
参考文献
1 王普善.中药川芎化学成分及其生理活性研究的回顾与展望.医药工业，1988,19(12):553～554
收稿日期:1998-03-15, http://www.100md.com
单位：沈阳药科大学药学系， 沈阳 110015
关键词：大川芎丸；血栓；血小板聚集
沈阳药科大学学报990221 摘 要 大川芎丸水煎液对ADP诱导的家兔、大白鼠、小白鼠体内血小板聚集有明显的抑制作用.大川芎丸水煎液4.5 g/kg具有抑制家兔血栓形成的作用.
分类号 R96
Effects of Da Chuanxiong Pills on Platelet Aggregation
You Yueren,Lei Tianluo,Ma Tao,Kuang Rong,Yang Liang
, http://www.100md.com
Department of Pharmacy,Shenyang Pharmaceutical University, Shenyang 110015
Abstract The effects of Da Chuanxiong Pills(DCXP)on thrombosis were studied.Formation of thrombosis and platelet aggregation induced by ADP were inhibited in rabbits by taking orally 4.5 g/kg of the boiling water decoction(TBWE) of DCXP.The platelet aggregation induced by ADP were inhibited by taking orally 1,2 g/kg of TBWE in rats and 40,60 g/kg in mice,respectively.
, 百拇医药
Key words Da Chuanxiong Pills :thrombosis;platelet aggregation
大川芎丸为我国传统中药方，民间用于治疗“偏正头痛”、“首风眩晕”，我国历代本草均有述及〔1〕.作者初步探讨了大川芎丸的抗血栓及抗血小板聚集作用.
1 实验方法与结果
1.1 对家兔血栓形成的影响
取雄性家兔，用颈动脉穿线法形成血栓，4 h后取出血栓，计算湿重与体重之比.结果见表1.大川芎丸水煎液4.5 g/kg具有抑制血栓形成的作用.
1.2 对ADP诱导的家兔血小板聚集的影响
取雄性家兔，按表2分组给药.给药后3 h常规方法测定血小板聚集率，结果见表2.大川芎丸水煎液能明显抑制ADP诱导的家兔体内血小板聚集.
, http://www.100md.com
Tab.1 Effect of TBWE on thrombosis in rabbits Group
Dosage/
g.kg-1
n
Thrombosis weight/
rabbit weight
(
±s)/mg.kg-1Inhibition/
, 百拇医药
%
NS
8
16.2±5.2
TBWE
2.3
8
14.8±4.7
8.6
4.5
9
11.6±2.5*
28.4
, http://www.100md.com
Compared with NS *P<0.05Tab.2 Effect of TBWE on rabbit platelet aggregation induced by ADP in vivo Group
Dosage/g.kg-1
n
Agg/
±s,%Inhibition/%
NS
6
46.2±8.1
, http://www.100md.com
TBWE
4\^5
6
18.7±5.6**
59.5
Compared with NS **P<0.01
1.3 对ADP诱导的大白鼠血小板聚集的影响
取雄性大白鼠，按表3分组给药，分别于给药前和给药后1 h依常规方法测定血小板聚集率，结果见表3.大川芎丸水煎液能明显抑制ADP诱导的大白鼠体内血小板聚集.
Tab.3 Effect of TBWE on rat platelet aggregation induced by ADP in vivo Group
, http://www.100md.com
Dosage/
g.kg-1
n
Agg/
±s,%Inhibition/%
0
1
NS
6
49.8±13.7
57.0±4.9
, http://www.100md.com
TBWE
1
6
47.8±8.1
34.9±8.5**
38.8
2
6
53.1±15.0
33.1±8.4
41.9
Compared with NS **P<0.01Tab.4 Effect of TBWE on mice platelet aggregation induced by ADP in vivo Group
, 百拇医药
Dosage/g.kg-1
n
Agg/
±s,%Inhibition/%
NS
10
44.5±7.4
TBWE
40
8
, http://www.100md.com 24.3±12.5**
40.7
60
8
17.7±7.7**
59.5
Compared with NS **P<0.01
1.4 对ADP诱导的小白鼠血小板聚集的影响
取雄性小白鼠，按表4分组给药，于给药后1 h取血依常规方法测定血小板聚集率，结果见表4.大川芎丸水煎液具有抗ADP诱导的小白鼠体内血小板聚集作用.
2 结论
大川芎丸水煎液抑制ADP诱导的家兔及大、小鼠体内血小板聚集，并抑制家兔血栓形成.
参考文献
1 王普善.中药川芎化学成分及其生理活性研究的回顾与展望.医药工业，1988,19(12):553～554
收稿日期:1998-03-15, http://www.100md.com