ENGLISH ABSTRACTS OF ORIGINAL ARTICLES
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肠外与肠内营养990321 Application of TNA in critical patients——a rep ort of 84 cases
ZHAO Huan-hua,SONG Xiu-qin,GAO Wu-xin et al
(Wuxi First People's Hospital，Wuxi 214002,China)
Abstract：Objectives:To improve the nutritional situation an d increase the cure rate in patients with critical diseases by parenteral nutrit ional support of total nutrient admixture(TNA). Methods:TNA wer e administered in 84 patients.The duration of TNA-nutritional support was 5～61 d ays,with a mean of 20.5 days.After nutritional support,the nutritional status wa s improved in 13 malnurished patients with colon cancer and the operations were completed with no complications.In mechanically ventilated 36 patients the nutri tional situation were improved and 31 patients were smoothly free of ventilator. Conclusions:The parenteral nutrition of total nutrient admixtu re is an important measure in the treatment of critical patients.
, http://www.100md.com
Key words：total nutrient admixture; critical patients
Continuous observation for the composition of human body
in hyperthyroidism patients in the period of perioperation
WANG Shu-feng,JIA Ru-mei,WU Wei-zhong et al
(Department of Surgery,2nd Hospital of Hebei Medical University,Sh ijiazhuang 050000,China)
Abstract:Objectives:To explore the chagnes in nutir tional situation of the patients with hyperthyroidism at admission and in the pe r iod of perioperation with (BFA-100). Methods:Indeses (WT/HT,TS F,A MC,GS,BF) were conducted in 85 patients with hyperthyroidism within 3 day of adm ission.Nutritional situation was continuously evaluated in 54 patients 1 day bef ore and 5 day after operation with same method. Results:Malnutr ition in different degrees were found to be 96%(82/85) at admission.Wit h preo perative preparation, WT/HT,TSF,BF were significantly higher at the day before o p eration than those at admission.No significant changes were found after operation. Conclusions:Malnutrition of the patients with hyperthyroidism could be determined by the measurement of composition of human body with bioelectricity impedance.
, 百拇医药
Key words:hyperthyroidism; nutrition value; electrical impedanc e; perioperation period
Nutritional support in patients with chronic heart dysfunction
CHEN Bo-jun,ZHANG Min-zhou,ZENG Ying-hong
(The Guangdong Province Hospital of Traditional Medicine，Guangzhou 510120,China )
Abstract: Objectives:To observe the role of parenteral nutrition in patients with chronic heart dysfunction. Methods:36 cases of patients were divided into two groups.All patients rec eived the regular therapy against heart dysfunction.Of them,20 cases were supported wi th parenteral nutrition.The other patients were as controls.The clinical effecti veness and indexes were compared between the two groups before and after the tre atment. Results:The rate of clinical improvement was 85% in parenteral nutrition g roup,s ignificantly different from that in the control group(50%).The SV,CO and EF of l eft heart were obviously increased after PN. Conclusions:Nutritional support is helpful to improve the heart function in chronic heart dysfunction pateints.
, http://www.100md.com
Key words:nutritional support; parenteral; heart dysfunction
Effect of 11.4%Novamin on protein metabolism in postoperative patients
QUAN Zhu-fu,NI Yuan-hong,LI Hong et al
(Research Institute of General Surgery,Nanjing General Hospital of PLA，Nanjing 210002,China)
Abstract：Objectives:The study was designed to obser ve the effect of 11.4%Novamin on protein metabolism in postoperative patients. Methods:70 cases of patients were randomly divided into two gr oups and were supported with total parenteral nutrition for 6 days after their a bdominal surgery.105 kJ(25 kcal)/(kg.d) of nonprotein calorie and 0.15 g/(kg.d ) of nitrogen were provided in every patient. 11.4%Novamin was used in one group a nd 7%Vamin was used in another group as control.Body weight,total protein and al bumin concentrations and plasma amino acid profile were measured before and afte r the study.Daily nitrogen output in urine and other drainages was determined an d nitrogen balance was calculated during the TPN period. Results:The differences in body weight,total protein and albumin concentrations and am ino acid profile were not significant between the two groups.The difference in a ccumulated nitrogen balance was significant,(-82.2±24.7)mg/kg body weight in 11 .4%Novamin group and (-171.1±201.6)mg/kg body weight in 7%Vamin group(P<0.0 5 ). Conclusions:The use of 11.4%Novamin in postoperative patient s is helpful to further improve the nitrogen balance when compared with 7%Vamin.
, 百拇医药
Key words：pareenteral nutrition; 11.4%Novamin; nitrogen balance
The research of total parenteral nutrition plus recom binant human growth hormone in patients following major abdominal surgery
RAN Jiang-hua,GUO Qun,ZHANG Jia-ye et al
(Department of General Surgery,the 2nd Affiliated Hospital of Kunm ing Medical College,Kunming 650101,China)
Abstract:Objectives:To research the effects of usin g recombinant human growth hormone(rhGH) with total parenteral nutrition(TPN) on nitrogen balance and nutritional state in patients following major abdominal sur gery. Methods:We randomly selected 27 patients receiving TPN after major abdominal surgery and distributed them to study group(rhGH+TPN,n =15) and control group(TPN only,n=12).After operation,every one was g iven rhGH 4U or placebo by hyperdermic injection for 7 days. Results:The resul ts showed that TPN+rhGH increased the nitrogen balance,the level of plasma album in and transferrin,the body weight and creatinin height index(CHI).But the thick ness of triceps skin fold(TSF) had no significant change. Conclusions: The rhGH can improve the effects of TPN.
, http://www.100md.com
Key words： recombinant growth hormone; total parenteral nutrition; major abdominal surgery; nitrogen balance
Intralipid decreases the release of oxygen radicals from phag ocytes
WU Guo-hao,Connie Jarstrand*,Jorgen Nordenstrom*
(Department of Surgery,Zhongshan Hospital,Shanghai Medical University，Shan ghai,200032,China; *Department of Clinical Bacteriology and Surgery,Huddinge University Ho spital,Karolinska Institute,Sweden )
, http://www.100md.com
Abstract:Objectives:To study the effect of Intralip id on the release of oxygen radicals from phagocytes in vitro. Meth ods: Human polymorphonuclear neutrophils(PMN) were purified and incubated eit her with purified lipopolysaccharides(LPS) or with Intralipid.The release of oxy gen radicals was measured by the nitroblue tetrazolium(NBT) test. Resul ts:The incubation of PMN with LPS increased the release of oxygen radica ls.However,when the PMN were incubated with LPS together with Intralipid,the rel ease of oxygen radicals was significantly decreased. Conclusions:Intralipid might inhibit the effect of LPS on the PMN in an infection with Gra m-negtive bacteria.
, 百拇医药
Key words：Intralipid; phagocyte; oxygen radicals
Nutritional support for patient will liver transplantation
XU Ping,XIE Min
(Affiliated Gulou Hospital of Medical College,Nanjing University,Nanjing 210008 ,China)
Abstract：Objectives:To review the methods of nutrit ional support after liver transplantation. Methods:An analysis of the nutritional support and of the nutritional status in two p atients was made af ter orthotopic liver tranplantation(OLT).Total parenteral nutrition(TPN) was ad minis tered within first two or three days after the operation.The combination of enteric nutrition(EN) and parentera l nutrition(PN) was adopted three or four days after the OLT,and then a gradual intake of oral food was used. Results:Both patients surv ived with good health. Conclusions:Depending on the recovery of the transplanted liver functions,the supply of nutrition should be controlled d uring the f irst few days,and then gradually increased.Once the gastroenteric functions of p atients recov er,it is advisable to start EN as soon as possible.
, 百拇医药
Key words：liver transplantation; nutritional support
Influence of short chain fatty acids(SCFAs) on small intestine morphology and epith elial cells proliferation in TPN-fed rats
LI Ke-zhou,LI You-sheng,BAO Yang et al
(Research Institute of General Surgery Nanjing General Hospital of PLA，Nanjing 210002，China)
Abstract:Objectives:Total pareteral nutrition (TPN) has prov ed to be a valuable method of n utrtion support.However,when supplid as the s ole source of nutrition to normal anim als ,TPN produced atrophy of the small intestine. SCFAs were shown to stimul ate mucosal cell mitotic activity,this study determined whether the addition of SC FAs could prevent intestine mucosal atrophy produced by TPN. Methods: Thirty adult Wistar(RT1K) rats were clarified into three groups.With ten rats served as sham operation control .Tewty rats had catheters inserted into the superior vena cava,of which ten was sustained with classical TPN and o thers with TPN plus SCFAs(sodium acetate,prop ionate,and butyrate) for 14 days. Smll intestine villi hight,width,crypt depth,and epithelial cell proliferation index(PI) were study and compared. Results:Animals receiving only classical TPN h ad significant decreas of small intestine villi hight(162.8±18.3) μm,width(71.4±14.5) μm and cry pt depth(73.2±8.2) μm. Epithelial cell proliferation index(PI) was also very low(3.76±1.42) compared to control(5.51±2.14).In SCFAs-TPN trea ted rats, morphological parameters and prolif eration index were all much higher tha n classical TPN-fed rats.There were no apparent difference between SCFAs-TPN group and sham operation control group. Conclusions:The results suggest that SCFAs ma y be used to decrease the mucosal atrophy that commonly occurs after TPN support and other gastrointestinal inhibition state.
, 百拇医药
Key words：short chain fatty acids; total parenteral nutrition ; morphology; proliferation i ndex
Effects of enteralnutrient IMPACT on immune function of traum atic rat
ZHANG Li-hua,ZHANG Xiao-qiao,LI Jie-shou
(Research Institute of General Surgery,Nanjing General Hospital of PLA，Nanji ng 210002,China)
Abstract:Objectives:To evaluate the immunomodulato r y effect of enteral nutrient IMPACT,containing immunomodulator arginine-fish oi l and RNA,on the postraumatic immunosuppression of organism. Methods:The traumatic models were established by bilateral femoral fracture in 21 W istar rats.They were devided into 3 groups randomly according to the different n utrient:Ensure group，Nutrison group and Impact group.They were all fed intragas trically with each enteral nutrient which provides 837 kJ/kg per day for 5 days. The changes of body weight,serum albumin,peripheral blood T lymphocyte subsets a nd blood routine examination,quantitative microscopy of spleen were analysed. Results:Body weights and serum albumin levels of 3 groups decrea sed after trauma.In rats fed with IMPACT,the indexes of immune function were imp roved significantly. Conclusions:The posttraumatic immunosuppre ssion can be corrected by enteral nutrient containing immunomodulator.
, 百拇医药
Key words:trauma; enteral nutrition; immune function
PEG——A new way of enteral nutrition feeding
ZHU Xian-li,YANG Shu-xu,GAO Min et al
(Sir Run Run Shaw Hospital,Zhejiang University，Hangzhou 310016，China)
Abstract：Objectives:To evaluate the value of percut aneous endoscopy gastrostomy(PEG) in nutrition support of neurosurgical and neur ological patients. Methods:Thirty patients had undergone PEG. Results:Nutritional status was improved in the survival patients and the lung infections were controlled.Seven patients recovered with oral intake and 10 patient were discharge from hospital with the feeding tube for further rehabi litation,3 patients died from the deterioration of the original disease.Two case s had the inflammation at the PEG wound but easily treated.No other complications of PEG occured. Conclusions:PEG is safe and effective for ente ral nutrition in some neurosurgical and neurological patients.
Key words:percutaneous endoscopy gastrostomy； enteral nutrition, 百拇医药
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肠外与肠内营养990321 Application of TNA in critical patients——a rep ort of 84 cases
ZHAO Huan-hua,SONG Xiu-qin,GAO Wu-xin et al
(Wuxi First People's Hospital，Wuxi 214002,China)
Abstract：Objectives:To improve the nutritional situation an d increase the cure rate in patients with critical diseases by parenteral nutrit ional support of total nutrient admixture(TNA). Methods:TNA wer e administered in 84 patients.The duration of TNA-nutritional support was 5～61 d ays,with a mean of 20.5 days.After nutritional support,the nutritional status wa s improved in 13 malnurished patients with colon cancer and the operations were completed with no complications.In mechanically ventilated 36 patients the nutri tional situation were improved and 31 patients were smoothly free of ventilator. Conclusions:The parenteral nutrition of total nutrient admixtu re is an important measure in the treatment of critical patients.
, http://www.100md.com
Key words：total nutrient admixture; critical patients
Continuous observation for the composition of human body
in hyperthyroidism patients in the period of perioperation
WANG Shu-feng,JIA Ru-mei,WU Wei-zhong et al
(Department of Surgery,2nd Hospital of Hebei Medical University,Sh ijiazhuang 050000,China)
Abstract:Objectives:To explore the chagnes in nutir tional situation of the patients with hyperthyroidism at admission and in the pe r iod of perioperation with (BFA-100). Methods:Indeses (WT/HT,TS F,A MC,GS,BF) were conducted in 85 patients with hyperthyroidism within 3 day of adm ission.Nutritional situation was continuously evaluated in 54 patients 1 day bef ore and 5 day after operation with same method. Results:Malnutr ition in different degrees were found to be 96%(82/85) at admission.Wit h preo perative preparation, WT/HT,TSF,BF were significantly higher at the day before o p eration than those at admission.No significant changes were found after operation. Conclusions:Malnutrition of the patients with hyperthyroidism could be determined by the measurement of composition of human body with bioelectricity impedance.
, 百拇医药
Key words:hyperthyroidism; nutrition value; electrical impedanc e; perioperation period
Nutritional support in patients with chronic heart dysfunction
CHEN Bo-jun,ZHANG Min-zhou,ZENG Ying-hong
(The Guangdong Province Hospital of Traditional Medicine，Guangzhou 510120,China )
Abstract: Objectives:To observe the role of parenteral nutrition in patients with chronic heart dysfunction. Methods:36 cases of patients were divided into two groups.All patients rec eived the regular therapy against heart dysfunction.Of them,20 cases were supported wi th parenteral nutrition.The other patients were as controls.The clinical effecti veness and indexes were compared between the two groups before and after the tre atment. Results:The rate of clinical improvement was 85% in parenteral nutrition g roup,s ignificantly different from that in the control group(50%).The SV,CO and EF of l eft heart were obviously increased after PN. Conclusions:Nutritional support is helpful to improve the heart function in chronic heart dysfunction pateints.
, http://www.100md.com
Key words:nutritional support; parenteral; heart dysfunction
Effect of 11.4%Novamin on protein metabolism in postoperative patients
QUAN Zhu-fu,NI Yuan-hong,LI Hong et al
(Research Institute of General Surgery,Nanjing General Hospital of PLA，Nanjing 210002,China)
Abstract：Objectives:The study was designed to obser ve the effect of 11.4%Novamin on protein metabolism in postoperative patients. Methods:70 cases of patients were randomly divided into two gr oups and were supported with total parenteral nutrition for 6 days after their a bdominal surgery.105 kJ(25 kcal)/(kg.d) of nonprotein calorie and 0.15 g/(kg.d ) of nitrogen were provided in every patient. 11.4%Novamin was used in one group a nd 7%Vamin was used in another group as control.Body weight,total protein and al bumin concentrations and plasma amino acid profile were measured before and afte r the study.Daily nitrogen output in urine and other drainages was determined an d nitrogen balance was calculated during the TPN period. Results:The differences in body weight,total protein and albumin concentrations and am ino acid profile were not significant between the two groups.The difference in a ccumulated nitrogen balance was significant,(-82.2±24.7)mg/kg body weight in 11 .4%Novamin group and (-171.1±201.6)mg/kg body weight in 7%Vamin group(P<0.0 5 ). Conclusions:The use of 11.4%Novamin in postoperative patient s is helpful to further improve the nitrogen balance when compared with 7%Vamin.
, 百拇医药
Key words：pareenteral nutrition; 11.4%Novamin; nitrogen balance
The research of total parenteral nutrition plus recom binant human growth hormone in patients following major abdominal surgery
RAN Jiang-hua,GUO Qun,ZHANG Jia-ye et al
(Department of General Surgery,the 2nd Affiliated Hospital of Kunm ing Medical College,Kunming 650101,China)
Abstract:Objectives:To research the effects of usin g recombinant human growth hormone(rhGH) with total parenteral nutrition(TPN) on nitrogen balance and nutritional state in patients following major abdominal sur gery. Methods:We randomly selected 27 patients receiving TPN after major abdominal surgery and distributed them to study group(rhGH+TPN,n =15) and control group(TPN only,n=12).After operation,every one was g iven rhGH 4U or placebo by hyperdermic injection for 7 days. Results:The resul ts showed that TPN+rhGH increased the nitrogen balance,the level of plasma album in and transferrin,the body weight and creatinin height index(CHI).But the thick ness of triceps skin fold(TSF) had no significant change. Conclusions: The rhGH can improve the effects of TPN.
, http://www.100md.com
Key words： recombinant growth hormone; total parenteral nutrition; major abdominal surgery; nitrogen balance
Intralipid decreases the release of oxygen radicals from phag ocytes
WU Guo-hao,Connie Jarstrand*,Jorgen Nordenstrom*
(Department of Surgery,Zhongshan Hospital,Shanghai Medical University，Shan ghai,200032,China; *Department of Clinical Bacteriology and Surgery,Huddinge University Ho spital,Karolinska Institute,Sweden )
, http://www.100md.com
Abstract:Objectives:To study the effect of Intralip id on the release of oxygen radicals from phagocytes in vitro. Meth ods: Human polymorphonuclear neutrophils(PMN) were purified and incubated eit her with purified lipopolysaccharides(LPS) or with Intralipid.The release of oxy gen radicals was measured by the nitroblue tetrazolium(NBT) test. Resul ts:The incubation of PMN with LPS increased the release of oxygen radica ls.However,when the PMN were incubated with LPS together with Intralipid,the rel ease of oxygen radicals was significantly decreased. Conclusions:Intralipid might inhibit the effect of LPS on the PMN in an infection with Gra m-negtive bacteria.
, 百拇医药
Key words：Intralipid; phagocyte; oxygen radicals
Nutritional support for patient will liver transplantation
XU Ping,XIE Min
(Affiliated Gulou Hospital of Medical College,Nanjing University,Nanjing 210008 ,China)
Abstract：Objectives:To review the methods of nutrit ional support after liver transplantation. Methods:An analysis of the nutritional support and of the nutritional status in two p atients was made af ter orthotopic liver tranplantation(OLT).Total parenteral nutrition(TPN) was ad minis tered within first two or three days after the operation.The combination of enteric nutrition(EN) and parentera l nutrition(PN) was adopted three or four days after the OLT,and then a gradual intake of oral food was used. Results:Both patients surv ived with good health. Conclusions:Depending on the recovery of the transplanted liver functions,the supply of nutrition should be controlled d uring the f irst few days,and then gradually increased.Once the gastroenteric functions of p atients recov er,it is advisable to start EN as soon as possible.
, 百拇医药
Key words：liver transplantation; nutritional support
Influence of short chain fatty acids(SCFAs) on small intestine morphology and epith elial cells proliferation in TPN-fed rats
LI Ke-zhou,LI You-sheng,BAO Yang et al
(Research Institute of General Surgery Nanjing General Hospital of PLA，Nanjing 210002，China)
Abstract:Objectives:Total pareteral nutrition (TPN) has prov ed to be a valuable method of n utrtion support.However,when supplid as the s ole source of nutrition to normal anim als ,TPN produced atrophy of the small intestine. SCFAs were shown to stimul ate mucosal cell mitotic activity,this study determined whether the addition of SC FAs could prevent intestine mucosal atrophy produced by TPN. Methods: Thirty adult Wistar(RT1K) rats were clarified into three groups.With ten rats served as sham operation control .Tewty rats had catheters inserted into the superior vena cava,of which ten was sustained with classical TPN and o thers with TPN plus SCFAs(sodium acetate,prop ionate,and butyrate) for 14 days. Smll intestine villi hight,width,crypt depth,and epithelial cell proliferation index(PI) were study and compared. Results:Animals receiving only classical TPN h ad significant decreas of small intestine villi hight(162.8±18.3) μm,width(71.4±14.5) μm and cry pt depth(73.2±8.2) μm. Epithelial cell proliferation index(PI) was also very low(3.76±1.42) compared to control(5.51±2.14).In SCFAs-TPN trea ted rats, morphological parameters and prolif eration index were all much higher tha n classical TPN-fed rats.There were no apparent difference between SCFAs-TPN group and sham operation control group. Conclusions:The results suggest that SCFAs ma y be used to decrease the mucosal atrophy that commonly occurs after TPN support and other gastrointestinal inhibition state.
, 百拇医药
Key words：short chain fatty acids; total parenteral nutrition ; morphology; proliferation i ndex
Effects of enteralnutrient IMPACT on immune function of traum atic rat
ZHANG Li-hua,ZHANG Xiao-qiao,LI Jie-shou
(Research Institute of General Surgery,Nanjing General Hospital of PLA，Nanji ng 210002,China)
Abstract:Objectives:To evaluate the immunomodulato r y effect of enteral nutrient IMPACT,containing immunomodulator arginine-fish oi l and RNA,on the postraumatic immunosuppression of organism. Methods:The traumatic models were established by bilateral femoral fracture in 21 W istar rats.They were devided into 3 groups randomly according to the different n utrient:Ensure group，Nutrison group and Impact group.They were all fed intragas trically with each enteral nutrient which provides 837 kJ/kg per day for 5 days. The changes of body weight,serum albumin,peripheral blood T lymphocyte subsets a nd blood routine examination,quantitative microscopy of spleen were analysed. Results:Body weights and serum albumin levels of 3 groups decrea sed after trauma.In rats fed with IMPACT,the indexes of immune function were imp roved significantly. Conclusions:The posttraumatic immunosuppre ssion can be corrected by enteral nutrient containing immunomodulator.
, 百拇医药
Key words:trauma; enteral nutrition; immune function
PEG——A new way of enteral nutrition feeding
ZHU Xian-li,YANG Shu-xu,GAO Min et al
(Sir Run Run Shaw Hospital,Zhejiang University，Hangzhou 310016，China)
Abstract：Objectives:To evaluate the value of percut aneous endoscopy gastrostomy(PEG) in nutrition support of neurosurgical and neur ological patients. Methods:Thirty patients had undergone PEG. Results:Nutritional status was improved in the survival patients and the lung infections were controlled.Seven patients recovered with oral intake and 10 patient were discharge from hospital with the feeding tube for further rehabi litation,3 patients died from the deterioration of the original disease.Two case s had the inflammation at the PEG wound but easily treated.No other complications of PEG occured. Conclusions:PEG is safe and effective for ente ral nutrition in some neurosurgical and neurological patients.
Key words:percutaneous endoscopy gastrostomy； enteral nutrition, 百拇医药