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自动微粒分析仪检测输液微粒
http://www.100md.com 《西北药学杂志》1999年第3期
     作者:吴 瑜 景志强0o, http://www.100md.com

    单位:江苏石油勘探局职工医院 江都 2252610o, http://www.100md.com

    关键词:0o, http://www.100md.com

    注射液中不溶性微粒可对人体造成危害 注射液中不溶性微粒可对人体造成危害。中国药典1995年版对输液中不溶性微粒检测的方法和限量作了规定。本文应用自动微粒分析仪检测注射液微粒,并与药典显微镜法进行比较。0o, http://www.100md.com

    1 仪器0o, http://www.100md.com

    WF9010自动微粒分析仪(南京电子医疗仪器厂)。XSP-16A显微镜(江南光学仪器厂)。0o, http://www.100md.com

    2 方法与结果0o, http://www.100md.com

    除生理盐水(NS)和葡萄糖氯化钠(GS-NS)注射液可直接测定外,其它不含电解质的注射液均加入不含微粒的自制0.9 g/L氯化钠溶液适量,使氯化钠含量为0.09 g/L。测定时将待测样品在净化台上翻转20次,倒入取样杯中测定。每个样品一次可连续自动测量10,25 μm微粒10次,结果(见表1)表明自动微粒仪与显微镜法无显著性差异。0o, http://www.100md.com

    表1 输液微粒测量结果(个/ml) 注射液0o, http://www.100md.com

    批号0o, http://www.100md.com

    自动微粒仪法0o, http://www.100md.com

    显微镜法0o, http://www.100md.com

    ≥25μm0o, http://www.100md.com

    ≥10 μm0o, http://www.100md.com

    ≥25μm0o, http://www.100md.com

    ≥10 μm0o, http://www.100md.com

    GS-NS0o, http://www.100md.com

    9709040o, http://www.100md.com

    0.20o, http://www.100md.com

    8.50o, http://www.100md.com

    0.30o, http://www.100md.com

    7.30o, http://www.100md.com

    9710150o, http://www.100md.com

    0.30o, http://www.100md.com

    6.60o, http://www.100md.com

    0.250o, http://www.100md.com

    5.50o, http://www.100md.com

    9711120o, http://www.100md.com

    0.10o, http://www.100md.com

    4.50o, http://www.100md.com

    0.20o, http://www.100md.com

    3.80o, http://www.100md.com

    50 g/L GS0o, http://www.100md.com

    9709100o, http://www.100md.com

    00o, http://www.100md.com

    4.60o, http://www.100md.com

    0.20o, http://www.100md.com

    3.80o, http://www.100md.com

    9710290o, http://www.100md.com

    0.40o, http://www.100md.com

    5.40o, http://www.100md.com

    0.30o, http://www.100md.com

    4.80o, http://www.100md.com

    100 g/L GS0o, http://www.100md.com

    9709170o, http://www.100md.com

    0.30o, http://www.100md.com

    4.60o, http://www.100md.com

    0.30o, http://www.100md.com

    4.00o, http://www.100md.com

    9709240o, http://www.100md.com

    00o, http://www.100md.com

    3.80o, http://www.100md.com

    0.10o, http://www.100md.com

    4.40o, http://www.100md.com

    9710070o, http://www.100md.com

    00o, http://www.100md.com

    3.80o, http://www.100md.com

    0.10o, http://www.100md.com

    4.60o, http://www.100md.com

    9711090o, http://www.100md.com

    0.30o, http://www.100md.com

    4.30o, http://www.100md.com

    0.20o, http://www.100md.com

    2.60o, http://www.100md.com

    9711260o, http://www.100md.com

    0.20o, http://www.100md.com

    8.20o, http://www.100md.com

    0.10o, http://www.100md.com

    6.70o, http://www.100md.com

    NS0o, http://www.100md.com

    9710220o, http://www.100md.com

    0.10o, http://www.100md.com

    5.60o, http://www.100md.com

    0.30o, http://www.100md.com

    6.50o, http://www.100md.com

    9711190o, http://www.100md.com

    0.10o, http://www.100md.com

    6.30o, http://www.100md.com

    0.20o, http://www.100md.com

    5.60o, http://www.100md.com

    (收稿:1998-11-08)(吴 瑜 景志强)