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高效液相色谱法测定双扑伪麻片中扑热息痛、盐酸伪麻黄碱、扑尔敏的含量
http://www.100md.com 《沈阳药科大学学报》1999年第3期
高效液相色谱|双扑伪麻片|扑热息痛|盐酸伪麻黄碱|扑尔敏
     作者:魏万峰 王 炜 李光耀

    单位:海南三叶药物研究所, 海口 570226

    关键词:高效液相色谱;双扑伪麻片;扑热息痛;盐酸伪麻黄碱;扑尔敏

    沈阳药科大学学报990313 摘 要 用高效液相色谱法,同时分离测定双扑伪麻片中扑热息痛、盐酸伪麻黄碱和扑尔敏的含量.线性范围:扑热息痛0.20~0.80 g/L,r=0.999 5;盐酸伪麻黄碱0.012~0.048 g/L,r=0.999 6;扑尔敏0.000 72~0.002 88 g/L,r=0.999 2.平均回收率(x±rsd)%分别为:扑热息痛(100.2±1.7)%;盐酸伪麻黄碱(99.6±1.4)%;扑尔敏(98.4±2.6)%.

    分类号 R914.1

    HPLC Determination of the Content of Paracetamol,Pseudoephedrine Hydrochloride and Chlorphenamine

    Maleate in Pseudoephedrine Hydrochloride

    Compound Tablets

    Wei Wanfeng,Wang Wei,Li Guangyao

    Hainan Sanye Medicine Research Institute,Haikou 570226

    Abstract A HPLC method was used to determine the content of the three components in pseudoephedrine hydrochloride compound tablets.A better linearity and good correlation coefficient were obtained from 0.20 g/L~0.08 g/L of paracetamol(r=0.999 5);0.012 g/L~0.048 g/L of pseudoephedrine hydrochloride(r=0.999 6);0.000 72 g/L~0.002 88 g/L of chlorphenamine maleate(r=0.999 2).The mean recoveries and RSD of the three components were (100.2±1.7)%,(99.6±1.4)%,(98.4±2.6)% respectively.The method is accurate,rapid and simple and can be used for the quantitive analysis of pseudoephedrine hydrochloride compound tablets. ......

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