微量脂微球载体前列腺素E1静注治疗慢性重度乙型肝炎疗效观察
作者：鲁 军 沈建琴 蔡新凤 沈士俊
单位：313000 浙江省湖州市第一人民医院
关键词：
浙江临床医学000110
摘 要：目的：观察并比较微量脂微球载体前列腺素E1(LipoPGE)与丹参注射液治疗慢性重度乙型病毒性肝炎的疗效。方法：慢性重度乙肝40例分2组，每组各20例。PGE组(男性15例，女性5例；年龄36±9岁)用脂微球载体前列腺素E110ug加入生理盐水10ml中静推，qd×20天；复方丹参组(男性16例，女性4例；年龄39±7岁)用复方丹参注射液16ml加入5%GS300ml中静滴，qd×20天。结果：PGE组与复方丹参组治疗后STB、ALT、AST降幅无显著差异(P>0.05)。但治疗总有效率PGE组为90%，复方丹参组为75%(P<0.05)。结论：微量脂微球前列腺素E1治疗慢性重度乙肝优于复方丹参。
, 百拇医药
Intravenous Micro-dose Prostaglandin E1 Corporated in Lipid Microspheres is Better than Radix Salviae Miltiorrhizae Compound Injection Drip in treating Serious Chronic Hepatitis B
Lu Jun
Abstract：Objective: To investigate and compare the effect of injection of microdosage prostaglandin E1 corporated in lipid microspheres (Lipo PGE1 ) and Radix Salviae Miltiorrhizae (RSM)compound in treatment of the serious chronic hepatitis B. Methods: Forty patients with serious chronic hepatitis B were randonly divided into two groups, each with twenty patients. The patients in Lipo PGE1 group were treacted by injection Lipo PGE1 10 ug in 0.9% sodium Chloride 10 ml, iv, qd for 20 d. The patients in RSM group were treated by RSM compund 16 ml in 5% glucose injection 300 ml iv, drip qd for 20 d. Results: No sihnficant difference were found between two groups in the decrease of serum total bilirubin(STB), alanine transaminase (ALT), and aspartate transaminase (AST) (P>0.05). The total effective rate were 90% and 75% respective (P<0.05). Conclusion: The efficacy of Lipo PGE1 is better than RSM compound in treatment of the seriouschronic hepatitis B.
, 百拇医药
Keywords：prostaglandin E1 Lipid microsphere Radix Salviae Miltiorrhizae hepatitis B intravenous infusion
参考文献：
[1]朴文姬，俞 红，周霞秋：前列腺素E.促肝细胞生长刺激因子对暴发性肝衰竭小鼠模型的保护作用.中华消化杂志，1995，15(2)：92-94.
[2]刘沛，王兆荃，张捷，等.前列腺素E1治疗实验性肝坏死的机理研究.中华内科杂志，1994，33(4)：241-243.
[3]Paul LB，G.Webb M，James KK，Hepatic and gastric cytoprotec tive effectc of long—term prostaglandin E1 administration in cirrhoticrats.Gastroenterology，1993，105(5)：1483-1489.
[4]Cattral MS，Altraif I，Greig PD，etal.Toxic effects ofintravenous and oral prostaglandin E thirapy in patients with liner disease.Am J Med，1994，97(4)：369-373.
[5]中华医学会传染病寄生虫病学会：病毒性肝炎防治方案(试行).中华传染病杂志，1995，13(4)：241-247., 百拇医药
单位：313000 浙江省湖州市第一人民医院
关键词：
浙江临床医学000110
摘 要：目的：观察并比较微量脂微球载体前列腺素E1(LipoPGE)与丹参注射液治疗慢性重度乙型病毒性肝炎的疗效。方法：慢性重度乙肝40例分2组，每组各20例。PGE组(男性15例，女性5例；年龄36±9岁)用脂微球载体前列腺素E110ug加入生理盐水10ml中静推，qd×20天；复方丹参组(男性16例，女性4例；年龄39±7岁)用复方丹参注射液16ml加入5%GS300ml中静滴，qd×20天。结果：PGE组与复方丹参组治疗后STB、ALT、AST降幅无显著差异(P>0.05)。但治疗总有效率PGE组为90%，复方丹参组为75%(P<0.05)。结论：微量脂微球前列腺素E1治疗慢性重度乙肝优于复方丹参。
, 百拇医药
Intravenous Micro-dose Prostaglandin E1 Corporated in Lipid Microspheres is Better than Radix Salviae Miltiorrhizae Compound Injection Drip in treating Serious Chronic Hepatitis B
Lu Jun
Abstract：Objective: To investigate and compare the effect of injection of microdosage prostaglandin E1 corporated in lipid microspheres (Lipo PGE1 ) and Radix Salviae Miltiorrhizae (RSM)compound in treatment of the serious chronic hepatitis B. Methods: Forty patients with serious chronic hepatitis B were randonly divided into two groups, each with twenty patients. The patients in Lipo PGE1 group were treacted by injection Lipo PGE1 10 ug in 0.9% sodium Chloride 10 ml, iv, qd for 20 d. The patients in RSM group were treated by RSM compund 16 ml in 5% glucose injection 300 ml iv, drip qd for 20 d. Results: No sihnficant difference were found between two groups in the decrease of serum total bilirubin(STB), alanine transaminase (ALT), and aspartate transaminase (AST) (P>0.05). The total effective rate were 90% and 75% respective (P<0.05). Conclusion: The efficacy of Lipo PGE1 is better than RSM compound in treatment of the seriouschronic hepatitis B.
, 百拇医药
Keywords：prostaglandin E1 Lipid microsphere Radix Salviae Miltiorrhizae hepatitis B intravenous infusion
参考文献：
[1]朴文姬，俞 红，周霞秋：前列腺素E.促肝细胞生长刺激因子对暴发性肝衰竭小鼠模型的保护作用.中华消化杂志，1995，15(2)：92-94.
[2]刘沛，王兆荃，张捷，等.前列腺素E1治疗实验性肝坏死的机理研究.中华内科杂志，1994，33(4)：241-243.
[3]Paul LB，G.Webb M，James KK，Hepatic and gastric cytoprotec tive effectc of long—term prostaglandin E1 administration in cirrhoticrats.Gastroenterology，1993，105(5)：1483-1489.
[4]Cattral MS，Altraif I，Greig PD，etal.Toxic effects ofintravenous and oral prostaglandin E thirapy in patients with liner disease.Am J Med，1994，97(4)：369-373.
[5]中华医学会传染病寄生虫病学会：病毒性肝炎防治方案(试行).中华传染病杂志，1995，13(4)：241-247., 百拇医药