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甲氨蝶呤吸干乳剂的抗肿瘤作用
http://www.100md.com 《沈阳药科大学学报》2000年第3期
吸干乳剂|甲氨蝶呤|抗肿瘤
     作者:晏四平 曾红 苏德森

    单位:晏四平(北京生物制品研究所);曾红(沈阳药科大学药学系,沈阳 110015)

    关键词:吸干乳剂;甲氨蝶呤;抗肿瘤

    沈阳药科大学学报000302 摘 要 用吸干乳剂作为抗癌药物甲氨蝶呤(MTX)的载体,考察MTX对S180、H22、ESC 3种实体瘤和EAC腹水瘤的抑制作用,并初步考察了MTX制成吸干乳剂后对小鼠的毒性.结果表明:与MTX片剂相比,吸干乳剂能提高MTX对3种实体瘤和EAC的抑制作用.

    分类号 R965;R944.9

    A Study on the Antitumor Effects of the Methotrexate Dry Adsorbed Emulsion

    Yan Siping,Zeng Hong,Su Desen

    Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015

    Abstract Dry adsorded emulsion,as a new antitumor drug delivery system,was used to entrap the methotrexate(MTX).The antitumor effects of methotrexate dry adsorbed emulsion(MTXDAE)were studied on three solid tumors(Sarcosma180,Hepatoma22 and Ehrlich Solid carcinoma) and Ehrlich ascites carcinoma,and the preliminary toxicity test of the MTXDAE was also studied in this paper.The results showed that the dry adsorbed emulsion could increase the antitumor effects of the MTX on three solid tumors and EAC in mice,especially in higher doses.

    Key words dry adsorbed emulsion;methotrexate;antitumor effects

    吸干乳剂作为一种新型的口服给药系统 ......

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