赤土茯苓苷对离体大鼠心脏缺血再灌注损伤的保护作用
作者:新华·那比 艾尼瓦尔 周承明 张克锦
单位:新华·那比 艾尼瓦尔 周承明 张克锦(新疆医科大学药理教研室 乌鲁木齐 830054)
关键词:赤土茯苓苷;心肌缺血再灌注;脂质过氧化;普萘洛尔
西北药学杂志000309摘 要:采用Langendorff离体大鼠非循环灌流模型测定赤土茯苓苷对离体大鼠缺血再灌注损伤时心肌收缩力、冠脉阻力、心率的影响及其抗脂质过氧化作用。结果2mg/L,10mg/L,50mg/L赤土茯苓苷可保护缺血再灌注心肌超氧化物歧化酶与硒谷胱甘肽过氧化物酶,降低脂质过氧化产物丙二醛的含量,能增加再灌后冠脉流量、冠脉阻力,促进心肌收缩幅度的恢复,减轻心脏水肿,但对心率的影响未见统计学差异。
分类号:R285 文献标识码:A
Protective effects of smiglabrin on ischemic reperfused injury myocardium of rats
Xinhua Nabi ,Anny val ,Zhou Chengming ,Zhang Kejin
(Department of Pharmcology,Xinjiang Medical Cellege,Urumqi 830054)
Abstract:To study the protective actions and its mechanism of smiglabrin on ischemic reperfused injury myocardium using the model of langendorff non-circulation isolated working rat hearts. The results showed that smiglabrin given with 2mg/L,10mg/L and 50mg/L protected the activities of SOD and Se-GSH-Px,diminished the content of MDA in a concentration-dependent manner and decreased the coronary vascular resistance,improved contractive amplitude and diminished the edema of heart.But there was no statistical difference On heart rate.
Keywords:smiglabrin;myocardial ischemic-reperfusion;lipid peroxidation;propranolol
参考文献:
[1]张克锦,周承明,艾尼瓦尔.赤土茯苓醋酸乙酸提取物对儿茶酚胺作用的研究.中草药,1991,22(10):460
[2]杨庆仙,刘瑞禾,李凤英.赤土茯苓治疗冠心病的初步临床观察.中国新药杂志,1992,1(3):56
[3]李玉琪,周承明,张克锦.赤土茯苓黄酮苷对异丙肾上腺素诱发的急性小鼠心脏缺血的保护作用.中草药,1996,27(7):418
[4]Zou Gl,Gui XF,Zhang XL.Improvements in pyrogallol autoxidation method for the determination of SOD activity.Biochem Biophyics,1986,(4):71
[5]夏奕明,朱莲珍.血和组织中谷胱甘肽过氧化物酶活力的测定方法DTNB直接法.卫生研究,1987,16:29
[6]陈顺志,金有余,李常淳.过氧化脂质TBA显色的三种方法学比较.临床检验杂志,1984,2(4):8
收稿日期:1999-12-02, 百拇医药
单位:新华·那比 艾尼瓦尔 周承明 张克锦(新疆医科大学药理教研室 乌鲁木齐 830054)
关键词:赤土茯苓苷;心肌缺血再灌注;脂质过氧化;普萘洛尔
西北药学杂志000309摘 要:采用Langendorff离体大鼠非循环灌流模型测定赤土茯苓苷对离体大鼠缺血再灌注损伤时心肌收缩力、冠脉阻力、心率的影响及其抗脂质过氧化作用。结果2mg/L,10mg/L,50mg/L赤土茯苓苷可保护缺血再灌注心肌超氧化物歧化酶与硒谷胱甘肽过氧化物酶,降低脂质过氧化产物丙二醛的含量,能增加再灌后冠脉流量、冠脉阻力,促进心肌收缩幅度的恢复,减轻心脏水肿,但对心率的影响未见统计学差异。
分类号:R285 文献标识码:A
Protective effects of smiglabrin on ischemic reperfused injury myocardium of rats
Xinhua Nabi ,Anny val ,Zhou Chengming ,Zhang Kejin
(Department of Pharmcology,Xinjiang Medical Cellege,Urumqi 830054)
Abstract:To study the protective actions and its mechanism of smiglabrin on ischemic reperfused injury myocardium using the model of langendorff non-circulation isolated working rat hearts. The results showed that smiglabrin given with 2mg/L,10mg/L and 50mg/L protected the activities of SOD and Se-GSH-Px,diminished the content of MDA in a concentration-dependent manner and decreased the coronary vascular resistance,improved contractive amplitude and diminished the edema of heart.But there was no statistical difference On heart rate.
Keywords:smiglabrin;myocardial ischemic-reperfusion;lipid peroxidation;propranolol
参考文献:
[1]张克锦,周承明,艾尼瓦尔.赤土茯苓醋酸乙酸提取物对儿茶酚胺作用的研究.中草药,1991,22(10):460
[2]杨庆仙,刘瑞禾,李凤英.赤土茯苓治疗冠心病的初步临床观察.中国新药杂志,1992,1(3):56
[3]李玉琪,周承明,张克锦.赤土茯苓黄酮苷对异丙肾上腺素诱发的急性小鼠心脏缺血的保护作用.中草药,1996,27(7):418
[4]Zou Gl,Gui XF,Zhang XL.Improvements in pyrogallol autoxidation method for the determination of SOD activity.Biochem Biophyics,1986,(4):71
[5]夏奕明,朱莲珍.血和组织中谷胱甘肽过氧化物酶活力的测定方法DTNB直接法.卫生研究,1987,16:29
[6]陈顺志,金有余,李常淳.过氧化脂质TBA显色的三种方法学比较.临床检验杂志,1984,2(4):8
收稿日期:1999-12-02, 百拇医药