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http://www.100md.com 《中国免疫学杂志》1999年第12期

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    中国免疫学杂志991205 摘 要 目的：从分泌抗狂犬病毒糖蛋白单克隆抗体(IgM)杂交瘤细胞中提取核糖核酸，研究其抗狂犬病毒的作用。方法：腹腔注射该种核糖核酸4 w后用狂犬病毒CVS株进行颅腔攻击。结果：该核糖核酸能明显延长动物的生存时间。结论：该核糖核酸对狂犬病毒且有一定的抵抗作用。

    中国图书分类号 R392.11

    Effect of anti-virus of RNA from hybridoma cell

    ZHANG Tao, FENG Jiang-Nan.

    Wuhan Institute of Biological Products, Ministry of Public Health, Wuhan 430060

    Abstract Objective:To study the possibility of RNA extracted from hybridoma cell as RNA and the relation between this RNA and tranditional RNA. Methods:Extracting RNA from the hybridoma cell which secrets monoclonal antibody(IgM)against the G-protein of rabies virus and injecting these RNA into cranial cavity in four weeks.Results:The RNA extracted from hybridoma cell could delay the dying of mice obviously. Conclusion: The RNA extracted from hybridoma cell had the same function as the traditional immune RNA,wihch could provided a new nethod to study the mechanism of immune RNA.

    Key words Immune RNA (iRNA) Hybridoma cell Monoclonal antibody Rabies virus

    免疫核糖核酸具有传递免疫反应的作用^[1] ......