http://www.100md.com
郑继宏 陈军
代谢性谷氨酸受体|第二信使|疼痛|伤害性易化
作者：郑继宏 陈军
单位：郑继宏(第四军医大学解剖学教研室，梁銶琚脑研究中心，西安 710032)；陈军(第四军医大学解剖学教研室，梁銶琚脑研究中心，西安 710032)
关键词：代谢性谷氨酸受体；第二信使；疼痛；伤害性易化
生理科学进展000207 摘要 代谢性谷氨酸受体是一个新的G-蛋白相关受体家族，各类亚型在分子生物学特征、神经药理学特征和中枢神经系统分布方面有所不同。根据其序列的同源性程度可将其分为三组。近来的研究证实代谢性谷氨酸受体在痛信息传递机制中具有重要作用。本文将对代谢性谷氨酸受体在上述机制中的可能作用作一综述。
学科分类号 R339.11
Metabotropic Glutamate Receptors and Its Contribution to the Mechanisms of Pain
ZHENG Ji-Hong， CHEN Jun
(Department of Anatomy and K.K. Leung Brain Research Centre,The Fourth Military Medical University, Xi'an 710032)
Abstract Metabotropic glutamate receptors (mGluRs) is a novel family of G protein-coupled receptors. Each subtype shows different features in the aspects of molecular biology, neuropharmacology and distribution in the central nervous system. It can be divided into three groups according to the extent of sequence homology. Recent experimental research has demonstrated that mGluRs play an important role in the transmission of pain. This article will review the possible roles of mGluRs in the processing of nociceptive information. ......
单位：郑继宏(第四军医大学解剖学教研室，梁銶琚脑研究中心，西安 710032)；陈军(第四军医大学解剖学教研室，梁銶琚脑研究中心，西安 710032)
关键词：代谢性谷氨酸受体；第二信使；疼痛；伤害性易化
生理科学进展000207 摘要 代谢性谷氨酸受体是一个新的G-蛋白相关受体家族，各类亚型在分子生物学特征、神经药理学特征和中枢神经系统分布方面有所不同。根据其序列的同源性程度可将其分为三组。近来的研究证实代谢性谷氨酸受体在痛信息传递机制中具有重要作用。本文将对代谢性谷氨酸受体在上述机制中的可能作用作一综述。
学科分类号 R339.11
Metabotropic Glutamate Receptors and Its Contribution to the Mechanisms of Pain
ZHENG Ji-Hong， CHEN Jun
(Department of Anatomy and K.K. Leung Brain Research Centre,The Fourth Military Medical University, Xi'an 710032)
Abstract Metabotropic glutamate receptors (mGluRs) is a novel family of G protein-coupled receptors. Each subtype shows different features in the aspects of molecular biology, neuropharmacology and distribution in the central nervous system. It can be divided into three groups according to the extent of sequence homology. Recent experimental research has demonstrated that mGluRs play an important role in the transmission of pain. This article will review the possible roles of mGluRs in the processing of nociceptive information. ......