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李荣凌 罗云 姜俊勇 袁才琼 于孝堂
甲磺酸培氟沙星|凝胶剂,ResearchandPreparationofPefloxacinMesylateGel
作者：李荣凌 罗云 姜俊勇 袁才琼 于孝堂
单位：李荣凌 罗云 姜俊勇 袁才琼(湖北医科大学附一医院药学部 武汉430060)；于孝堂(山东威海市立医院药剂科)
关键词：甲磺酸培氟沙星；凝胶剂
中国药师990520 摘 要 目的：研究甲磺酸培氟沙星凝胶剂的处方、制备工艺、质量控制及稳定性。方法：采用CMC-Na为基质制成凝胶剂，用双波长紫外分光光度法测定甲磺酸培氟沙星的含量。结果：平均回收率为100.0%，RSD为0.2%，稳定性好，临床疗效较好。结论：该制剂适合于临床应用。
Research and Preparation of Pefloxacin Mesylate Gel
Li Rongling, Luo Yun, Jiang Junyong, Yuan Caiqiong
The first affiliated Hospital of Hubei medical University, Wuhan, 430060, P.R.China
ABSTRACT Objective: To study the prescription, preparation, quality control and stability of pefloxcain meylate gel. Method: CMC-Na was used as base for preparating gel. The content of pefloxacin mesylate was determined by double-wave length UV. Result: The average recovery was 100.0% with RSD 0.2% (n=4). The gel was stable. Conclusion: The pefloxacin mesylate gel was available for clinical use. ......
单位：李荣凌 罗云 姜俊勇 袁才琼(湖北医科大学附一医院药学部 武汉430060)；于孝堂(山东威海市立医院药剂科)
关键词：甲磺酸培氟沙星；凝胶剂
中国药师990520 摘 要 目的：研究甲磺酸培氟沙星凝胶剂的处方、制备工艺、质量控制及稳定性。方法：采用CMC-Na为基质制成凝胶剂，用双波长紫外分光光度法测定甲磺酸培氟沙星的含量。结果：平均回收率为100.0%，RSD为0.2%，稳定性好，临床疗效较好。结论：该制剂适合于临床应用。
Research and Preparation of Pefloxacin Mesylate Gel
Li Rongling, Luo Yun, Jiang Junyong, Yuan Caiqiong
The first affiliated Hospital of Hubei medical University, Wuhan, 430060, P.R.China
ABSTRACT Objective: To study the prescription, preparation, quality control and stability of pefloxcain meylate gel. Method: CMC-Na was used as base for preparating gel. The content of pefloxacin mesylate was determined by double-wave length UV. Result: The average recovery was 100.0% with RSD 0.2% (n=4). The gel was stable. Conclusion: The pefloxacin mesylate gel was available for clinical use. ......