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鼻咽癌组织中CDK4和p16蛋白的表达
http://www.100md.com 《癌症》2000年第1期
鼻咽癌|免疫组化|CDK4|p16
     作者:戴文斌 陈蔚麟 蒋一强 任占平 唐德艳

    单位:戴文斌 陈蔚麟 蒋一强 任占平 唐德艳(广西柳州市人民医院病理科,广西柳州545001)

    关键词:鼻咽癌;免疫组化;CDK4;p16

    癌症000109

    摘 要:目的:为了观察CDK4和p16蛋白在鼻咽癌组织中的表达状态,探讨其与鼻咽癌的发生、发展关系。方法:应用S-P免疫组化法检测CDK4和p16蛋白在60例鼻咽癌和20例正常鼻咽部粘膜组织中的表达。结果:60例鼻咽癌中CDK4和p16蛋白表达率分别为66.7%和23.3%。高分化鳞癌p16蛋白的表达率明显高于低分化鳞癌(P<0.01)。21例淋巴结转移阳性组中p16蛋白的表达率低于14例阴性组(P<0.05),而CDK4蛋白表达率高于阴性组(P<0.05)。结论:提示CDK4蛋白的过度表达与p16蛋白的低表达可能涉及鼻咽癌的发生、发展过程。p16蛋白的表达缺失与鼻咽癌细胞分化、转移有关。CDK4蛋白的过度表达与鼻咽癌的转移有关。

    分类号:R739.63 文献标识码:A

    文章编号:1000467X(2000)01-0034-03

    A study of CDK4 and p16 protein in nasopharyngeal carcinoma

    DAI Wen bin1 CHEN Wei lin

    (Department of Pathology, Liuzhou People s Hospital, Liuzhou 545001,P.R.China)

    JIANG Yi qiang, et al.

    (Department of Pathology, Guangxi Medical University,Nanning 530021,P.R.China)

    Abstract:Objective:To evaluate the role of CDK4 and p16 protein expression in nasopharyngeal carcinoma (NPC). Methods:The S-P immunohistochemical method was used to detect the expression of CDK4 and p16 protein in 60 cases of NPC and 20 cases of normal tissues. Results:The positive expression rates of CDK4 and p16 protein in NPC were 66.7% and 23.3% , respectively.The positive expression rate of p16 protein was higher in well differentiated squamous cell carcinoma than in poorly differentiated squamous cell carcinoma (P<0.01). A significant correlation was found between low expression of p16 protein, over expression of CDK4 protein and cervical lymph node metastasis (P< 0.05 ).Conclusions:The results suggest that the inactivation of p16 protein and over expression of CDK4 protein may be involved in the carcinogenesis and development of NPC and implicated in tumor defferentiation and metastasis. ......

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