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    Compatibility and Stability of Cefoprazone Sodium with Ribavirin Injection in Three Infussion Solutions

    Li Gehui, Su Jia, Huang Jing

    (Guangxi Province Nanxishan Hospital, 541002, P.R.China)

    ABSTRACT Aim: To study compatibility and stability of cefoperazone sodium with ribavirin injection in 0.9 sodium chloride injection, 5 glucose and sodium chloride injection, and 10 glucose injection in three different temperatures(4 ¡æ, 25 ¡æ, 37 ¡æ). Method: Admixture of cefoperazone 1 g, ribavirin(1 mg/ml) 5 mg and 500 ml of 3 different infusion solutions were prepared and stored at 4 ¡æ, 25 ¡æ, 37 ¡æ. UV spectrophotometry was used to determine cefoperazone and rivavirin concentrations, pH and visual variation, the number of particle were also detected at different time during the period of study. Results: The number of particle is higher than the standard of China Pharmacopoeia at 4 ¡æ after 8 h; the concentrations, pH, color and visual variation and the number of particulate did not change and no precipitate and gas were produces at 25 ¡æ, 37 ¡æ after 8 h. Conclusion: The compatibility of cefoperazone with ribavirin injection in three infussion solutions are stable within 8 h, but the number of particulate may be increased at the lower temperature.
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    KEY WORDS Cefoperazone; Ribavirin; Compatibility; Stability¡ø

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