40例横纹肌肉瘤的病理分析
作者：魏守礼 朱振龙 贾茹 吕贵华 陈文磊 李其云
单位：魏守礼 朱振龙 吕贵华 陈文磊(河北医科大学第二医院病理科 050000)；贾茹 李其云(河北省人民医院病理科)
关键词：圆形细胞；横纹肌肉瘤；免疫组织化学
诊断病理学杂志000204摘 要：目的研究横纹肌肉瘤的形态学，阐明诊断和鉴别诊断。方法分析40例横纹肌肉瘤的组织类型、形态和免疫组化。结果分为3种亚型，胚胎型横纹肌肉瘤20例，含有星形、梭形和小圆形细胞形；腺泡状横纹肌肉瘤16例，以小圆形细胞及中圆形细胞为主；多形性横纹肌肉瘤4例，多为大圆形及中圆形细胞。全部肿瘤中，带状细胞，蝌蚪形细胞及多核细胞占27%，仅1例见到横纹。免疫组化阳性率分别为：Vimentin92%，desmin53.3%，平滑肌肌动蛋白87.5%及Myoglobin92.2%。结论在横纹肌肉瘤中少数为带状及蝌蚪状细胞，绝大多数为圆形细胞，后者具有重要诊断价值，免疫组化能增加诊断的正确性。
, http://www.100md.com
分类号：R738.7 文献标识码：A
文章编号：1007-8096(2000)02-0090-03
Pathological Analysis of 40 Cases of Rhabdomyosarcoma
Abstract：Objective To study morphological features of rhabdomyosarcoma and to elucidate its diagnosis and differential diagnosis.Methods Histologic patterns，morphologic changes and immunohistochemical stainings were analyzed in 40 cases of rhabdomyosarcomas. Results It was divided into three subtypes：20 cases of embryonal rhabdomyosarcoma(ERMS)consisting of stellate-shaped cells，spindle cells and small round cells；16 cases of alveolar rhabdomyosarcoma(ARMS)showing predominantly small and medium sized round cells；4 cases of polymorphic rhabdomyosarcoma(PRMS)appearing mostly large and medium sized cells.The strap-shaped cells，tadpole-shaped cells and multinucleated cells accounted for 27% in all the tumors.Crossstriations were founded in all cases but one.Positive rates of immunostainings were:vimentin in 92%cases，desmin 53.3%，smooth muscle actin 87.5%and myoglobulin 92.2%respectively.Conclusion There are less strap and tadpole-shaped cells and predominantly round cells in rhabdomyosarcomas，the latter playing an important role in the diagnosis.The immunohistochemical stainings can increase accuracy of the diagnosis.
, http://www.100md.com
Keywords：Round cells Rhabdomyosarcoma Immunohistochemistry
参考文献：
[1]Schurch W, Begin LR, Seemayer TA, et al. Heomorphic soft tissue myogenic sarcomas of adulthood. A reappraisal in the mid-1990s. Am J Surg Pathol,1996;20:131-147
[2]Kahn HJ, Yeger H, Kassim O, et al. Immunohistochemical and electron microscopic assessment of childhool rhabdomyosarcoma. Cancer,1983;51:1897-1903
, http://www.100md.com
[3]Miettinen M, Lehto VP, Badley RA, et al. Alveolar rhabdomysarcoma. Am J Pathol,1982;108:246-251
[4]Brocks JJ. Immunohistochemistry of soft tissue tumors, Myoglobin as a tumor marker for rhabdomyasacoma. Cancer,1982;50:1757-1763
[5]De Jong AS, Van Kessel-Van Vark M, Albus-Lutter CE, Pleomorphicrhabdomyosarcoma in adults：Immunohistochemistry as a tool for its diagnosis.Hum Pathol，1987;18:298-303
, 百拇医药
[6]Eusebi V，Ceccarelli C，Gorza L，et al.Immunocytochemistry of rhabdomyosarcoma，The use of four different markers.Am J Surg pathol，1986；10:293-299
[7]Folpe AL，Patterson K，Gown AM.Antibodies to desmin identify the blastemal component of nephroblastoma.Mod Pathol，1997;10:895-900
收稿日期：1999-06-28
修稿日期：1999-12-13, 百拇医药
单位：魏守礼 朱振龙 吕贵华 陈文磊(河北医科大学第二医院病理科 050000)；贾茹 李其云(河北省人民医院病理科)
关键词：圆形细胞；横纹肌肉瘤；免疫组织化学
诊断病理学杂志000204摘 要：目的研究横纹肌肉瘤的形态学，阐明诊断和鉴别诊断。方法分析40例横纹肌肉瘤的组织类型、形态和免疫组化。结果分为3种亚型，胚胎型横纹肌肉瘤20例，含有星形、梭形和小圆形细胞形；腺泡状横纹肌肉瘤16例，以小圆形细胞及中圆形细胞为主；多形性横纹肌肉瘤4例，多为大圆形及中圆形细胞。全部肿瘤中，带状细胞，蝌蚪形细胞及多核细胞占27%，仅1例见到横纹。免疫组化阳性率分别为：Vimentin92%，desmin53.3%，平滑肌肌动蛋白87.5%及Myoglobin92.2%。结论在横纹肌肉瘤中少数为带状及蝌蚪状细胞，绝大多数为圆形细胞，后者具有重要诊断价值，免疫组化能增加诊断的正确性。
, http://www.100md.com
分类号：R738.7 文献标识码：A
文章编号：1007-8096(2000)02-0090-03
Pathological Analysis of 40 Cases of Rhabdomyosarcoma
Abstract：Objective To study morphological features of rhabdomyosarcoma and to elucidate its diagnosis and differential diagnosis.Methods Histologic patterns，morphologic changes and immunohistochemical stainings were analyzed in 40 cases of rhabdomyosarcomas. Results It was divided into three subtypes：20 cases of embryonal rhabdomyosarcoma(ERMS)consisting of stellate-shaped cells，spindle cells and small round cells；16 cases of alveolar rhabdomyosarcoma(ARMS)showing predominantly small and medium sized round cells；4 cases of polymorphic rhabdomyosarcoma(PRMS)appearing mostly large and medium sized cells.The strap-shaped cells，tadpole-shaped cells and multinucleated cells accounted for 27% in all the tumors.Crossstriations were founded in all cases but one.Positive rates of immunostainings were:vimentin in 92%cases，desmin 53.3%，smooth muscle actin 87.5%and myoglobulin 92.2%respectively.Conclusion There are less strap and tadpole-shaped cells and predominantly round cells in rhabdomyosarcomas，the latter playing an important role in the diagnosis.The immunohistochemical stainings can increase accuracy of the diagnosis.
, http://www.100md.com
Keywords：Round cells Rhabdomyosarcoma Immunohistochemistry
参考文献：
[1]Schurch W, Begin LR, Seemayer TA, et al. Heomorphic soft tissue myogenic sarcomas of adulthood. A reappraisal in the mid-1990s. Am J Surg Pathol,1996;20:131-147
[2]Kahn HJ, Yeger H, Kassim O, et al. Immunohistochemical and electron microscopic assessment of childhool rhabdomyosarcoma. Cancer,1983;51:1897-1903
, http://www.100md.com
[3]Miettinen M, Lehto VP, Badley RA, et al. Alveolar rhabdomysarcoma. Am J Pathol,1982;108:246-251
[4]Brocks JJ. Immunohistochemistry of soft tissue tumors, Myoglobin as a tumor marker for rhabdomyasacoma. Cancer,1982;50:1757-1763
[5]De Jong AS, Van Kessel-Van Vark M, Albus-Lutter CE, Pleomorphicrhabdomyosarcoma in adults：Immunohistochemistry as a tool for its diagnosis.Hum Pathol，1987;18:298-303
, 百拇医药
[6]Eusebi V，Ceccarelli C，Gorza L，et al.Immunocytochemistry of rhabdomyosarcoma，The use of four different markers.Am J Surg pathol，1986；10:293-299
[7]Folpe AL，Patterson K，Gown AM.Antibodies to desmin identify the blastemal component of nephroblastoma.Mod Pathol，1997;10:895-900
收稿日期：1999-06-28
修稿日期：1999-12-13, 百拇医药