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胃癌双Y核心家系的遗传流行病学系列研究(Ⅱ)——分离比和遗传度的研究
http://www.100md.com 《癌症》2000年第6期
胃癌|双Y核心家系|分离比|遗传度
     作者:沈靖 王润田 邢厚恂 王理伟 王滨燕 李茂森 王建明 华召来 郭春华 王心如 徐希平

    单位:沈靖 王润田(北京医科大学流行病学与卫生统计学系,北京100083);邢厚恂 王心如(南京医科大学公共卫生学院,江苏南京210029);王理伟 李茂森 王建明 华召来 郭春华(扬中市肿瘤防治研究所,江苏扬中212200);王滨燕 徐希平(北京医科大学生态遗传与生殖卫生研究中心,北京100083)

    关键词:胃癌;双Y核心家系;分离比;遗传度

    癌症000622

    【摘要】目的:探讨遗传因素造成扬中市胃癌家族聚集性的作用方式与强度。方法:利用全新设计的双Y核心家系调查方法,对扬中市448个胃癌核心家系和437个对照家系,共5242人进行了分离比和遗传度研究。结果:祛除先证者后,扬中市胃癌家系的调整分离比为0.0143,表明同胞中胃癌发病率远低于单基因遗传病的0.25,符合多基因遗传方式;一级亲属中胃癌的调整遗传度为23.8%,男性(27.8%)明显高于女性(17.1%)。结论:扬中市胃癌呈明显家族聚集性的原因中,遗传易感性因素作用约占1/4,指出阐明遗传易感基因与环境因素交互作用的研究对胃癌病因预防至关重要。

    中图分类号:R735.2;R181.3 文献标识码:A

    文章编号:1000-467X(2000)06-0582-04

    A series of genetic epidemiological studies in gastric cancer

    pedigrees of double Y nuclear family-Ⅱ research

    on segregation ratio and heritability

    SHEN Jing, WANG Run-tian

    Department of Epidemiology and Biostatistics, Beijing Medical University, Beijing 100083,P.R.China

    XING Hou-xun

    School of Public Health,Nanjing Medical University,Nanjing 210029,P.R.China

    【 Abstract】 Objective: To explore the action pattern and intensity of genetic factor in the formation of gastric cancer familial aggregation in Yang Zhong. Methods: Using newly designed double Y nuclear family in 448 gastric cancer nuclear pedigrees and 437 control pedigrees which totally contained 5242 family members, we made a genetic epidemiological research on segregation ratio and heritability. Results: When the probands of gastric cancer cases were deleted, the adjusted segregation ratio in Yang Zhong families was 0.0143, which was significantly lower than that in mono-genetic diseases (0.25). It accords with model of multiple genetic diseases. Adjusted heritability in all first-degree relatives was 23.8% , and they were 27.8% and 17.1% in male and female respectively. Conclusion: Genetic susceptibility factor accounts for about 1/4 proportion in the formation of gastric cancer familial aggregation in Yang Zhong. It suggests that research on the interaction between genetic susceptibility and environmental factor is one of the most important steps in the primary prevention of gastric cancer. ......

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