当前位置:首页 > 医学版 > 期刊论文 > 肿瘤学 > 癌症 > 正文
编号:10292365
善得定对腹腔化疗中淋巴药物浓度的调节
http://www.100md.com 37c医学网
善得定|卡铂|化学疗法
     作者:汪邵平 王强 王元和

    单位:汪邵平 王元和(上海长征医院普外科,上海 200003);王强(上海长征医院普外科,上海 200003)

    关键词:善得定;卡铂;化学疗法

    癌症000421

    【摘要】目的:探讨善得定对腹腔化疗时淋巴药物浓度的调节作用。方法:大肠癌患者行卡铂腹腔化疗时联合应用善得定,观察腹腔淋巴结、门静脉铂浓度变化。结果:应用善得定后腹腔淋巴铂浓度2小时后提高,而门静脉铂浓度变化不大。结论:善得定可诱导卡铂腹腔淋巴化疗。

    中图分类号:R730.53 文献标识码:A 文章编号:1000-467X(2000)04-0356-02

    Sandostatin modulate lymph drug exposure following intraperitoneal chemotherapy

    WANG Shao- ping

    (Surgical Department of Liu- huaqiao Hospital. Guangzhou 510010, P.R. China)

    WANG Qiang WANG Yuan- he

    (Surgical Department of Changzhen Hospital. Shanghai,200003, P.R. China)

    【Abstract】 Objective: To examine modulating effect of Sandostatin to lymph drug concentration following intraperitoneal chemotherapy. Methods:Patients with colorectal cancer received 200 mg caboplatin intraperi to neally pre- operation were divided into two groups: 100 μ g sandostatin was injected subcutaneously in one group and no sandostatin imjection in another group as control.The platinum in portal vein plasma and local lymphatic nodes were monitored during the operation. Results: The platinum was increased 2hrs after sandostatin administration in lymphatic nodes but unchanged in portal vein. Conclusions: Sandostatin plays an interesting role in local lymphatic chemotherapy for these patients with intra- abdominal cancer and may be a new approach to deal with lymphatic metastisis in these high risk people. ......

您现在查看是摘要页,全文长 6793 字符