中图分类号R965；R285 文献标志码A 文章编号 1001-0408(2025)13-1604-06

    DOI 10.6039/j.issn.1001-0408.2025.13.09

    Study on mechanism of the efective substance groups from Artemisia ordosica inameliorating rheumatoid arthritis

    Hugejile'，WANG Qinghu'，ZHANG Xiaofeng'，KANG Xiurong2，BAI Yingchun1，Lihuricha’，GAO Mingxia’ (1.College of Traditional Mongolian Medicine，Inner Mongolia University for Nationalities，Inner Mongolia Tongliao O2800，China;2.Departmentof Medicine andFood，Tongliao Vocational Collge，Inner Mongolia Tongliao 028000，China)

    ABSTRACTOBJECTIVETo investigate theameliorating efect and mechanism ofthe efective substance groups fromArtemisia ordosica(AbbreviatedasHSH)onrheumatoidarthritis(RA)basedonclusterofdiferentiation4/lymphocytecel-specificproteintyrosinekinase/zeta-chain-assciatedproteinkinaseof70kDa/interleukin-17(CD4/LCK/ZAP70/IL-17)signalingpathway. METHOD Theratsweredivided into normal group，model group，HSHlow-dose，medium-dose and high-dosegroups(2.7， 10.8， 21.6mg/kg )and positive control group(Tripterygium glycosides tablet， 6.3mg/kg )，with1O rats in each group.Except for normal group ......