中图分类号 R969.4;R979.1 文献标志码A 文章编号 1001-0408(2025)13-1641-07

    DOI 10.6039/j.issn.1001-0408.2025.13.15

    Study on relationships of MS4A1 gene polymorphism with blood concentration and eficacy of rituximab in patientswithnon-Hodgkin'slymphoma

    SHI Feng'2，LIU Tao1，HUANG He¹ ，FANG Caifu1，GUAN Shaoxing2，ZHANG Zhang1，WANG Zhao1，FANG Xiaojiel，CHEN Zhuojia’，LIU Shu'(1.Dept. of Pharmacy，Cancer Center，Sun Yat-sen University，Guangzhou 510060，China;2.School of Pharmaceutical Sciences，Sun Yat-Sen University，Guangzhou 510o06，China)

    ABSTRACTOBJECTIVETo explore the efects ofCD20 coding gene(MS4AI)polymorphismon the blood concentrationand efcacyof rituximab in patients with non-Hodgkin'slymphoma.METHODS Aprospective observational study was conductedon 160 newlydiagnosed non-Hodgkin’slymphoma patients who received theR-CHOPregimen atthe Sun Yat Sen UniversityCancer Center from January2016 toDecember 2020 ......